TABLE 1

Effect of Probucol Treatments on Body Weight and on Plasma Levels of Total, LDL, and HDL Cholesterol and Triglycerides in WHHLMI Rabbits

	0 mo (10 mo old)		1 mo		3 mo		6 mo
Parameter	Probucol	Control	Probucol	Control	Probucol	Control	Probucol	Control
Body weight (kg)	3.7 ± 0.2	3.8 ± 0.1	3.8 ± 0.2	3.9 ± 0.2	4.0 ± 0.2	4.0 ± 0.3	3.9 ± 0.2	4.0 ± 0.3
Total cholesterol (mg/dL)	965 ± 138	967 ± 153	694 ± 71^*	741 ± 73^*	781 ± 48	716 ± 98^*	685 ± 220	660 ± 36^*
LDL (mg/dL)	675 ± 160	630 ± 167	509 ± 88	614 ± 97	587 ± 67	529 ± 85	483 ± 185^*	488 ± 50
HDL (mg/dL)	18 ± 3	14 ± 3	16 ± 3	14 ± 3	13 ± 2	14 ± 6	11 ± 3^*	12 ± 2
Triglycerides (mg/dL)	453 ± 147	366 ± 183	721 ± 241	447 ± 167	629 ± 154	526 ± 160^*	602 ± 216	572 ± 401

↵* P < 0.05 vs. corresponding value at month 0 (paired t test).
Data are presented as mean ± SD. No significant difference was seen in all parameters between probucol and control groups (Mann–Whitney U test).