TABLE 2

Biodistribution of 99mTc-L19-His in F9 Tumor–Bearing Mice

Biodistribution time (h)
Tissue0.2513524
Uptake (%ID/g)
 Spleen5.5 ± 0.62.7 ± 0.71.8 ± 0.21.2 ± 0.20.8 ± 0.2
 Liver6.1 ± 0.73.4 ± 0.44.3 ± 0.33.4 ± 0.72.5 ± 0.7
 Kidneys87.5 ± 5.2124.7 ± 6.3145.1 ± 22.3117.0 ± 12.972.4 ± 11.3
 Lung10.4 ± 1.85.2 ± 1.04.0 ± 1.24.1 ± 2.92.0 ± 0.6
 Bone*4.6 ± 0.95.4 ± 1.02.9 ± 1.53.4 ± 0.73.1 ± 0.9
 Heart5.2 ± 0.22.3 ± 0.21.1 ± 0.10.7 ± 0.10.4 ± 0.1
 Brain0.4 ± 0.10.2 ± 0.00.1 ± 0.00.1 ± 0.00.1 ± 0.0
 Thyroid4.9 ± 1.52.9 ± 0.12.7 ± 1.32.7 ± 1.11.1 ± 0.0
 Muscle*0.5 ± 0.20.6 ± 0.10.6 ± 0.10.4 ± 0.10.3 ± 0.1
 Stomach†2.0 ± 0.21.7 ± 0.12.1 ± 0.21.7 ± 0.31.1 ± 0.2
 Intestine‡1.4 ± 0.11.8 ± 0.22.4 ± 0.51.9 ± 0.81.2 ± 0.7
 Uterus3.2 ± 1.74.7 ± 1.34.9 ± 1.22.7 ± 0.84.4 ± 2.4
 Ovaries27.2 ± 18.810.2 ± 2.16.0 ± 1.06.9 ± 1.02.8 ± 0.5
 Tumor6.3 ± 2.08.4 ± 0.89.4 ± 1.48.1 ± 2.05.7 ± 2.0
 Blood18.7 ± 2.04.3 ± 0.11.7 ± 0.30.9 ± 0.10.2 ± 0.1
Excretion (%ID)
 Urine10.8 ± 3.314.8 ± 5.420.9 ± 5.521.3 ± 4.964.5 ± 6.5
 FecesNDND0.2 ± 0.30.6 ± 0.34.8 ± 1.0
Tumor/tissue ratio
 T/spleen1.2 ± 0.43.3 ± 1.15.3 ± 0.77.0 ± 2.36.6 ± 1.0
 T/liver1.1 ± 0.42.5 ± 0.52.2 ± 0.52.4 ± 0.62.3 ± 0.2
 T/kidneys0.1 ± 0.00.1 ± 0.00.1 ± 0.00.1 ± 0.00.1 ± 0.0
 T/lung0.6 ± 0.11.7 ± 0.42.5 ± 0.82.5 ± 1.22.9 ± 0.9
 T/muscle12.4 ± 1.415.5 ± 4516.4 ± 4.223.0 ± 9.522.9 ± 6.6
 T/blood0.4 ± 0.12.0 ± 0.25.7 ± 0.59.5 ± 2.623.6 ± 8.3
 T/intestine4.5 ± 1.74.8 ± 0.94.0 ± 0.74.9 ± 2.24.9 ± 1.4

  • ↵* Tissue aliquot only.

  • ↵† Without content.

  • ↵‡ With content.

  • ND = not detectable; T = tumor.

  • All data are presented as mean ± SD (n = 3).