TABLE 1

Biodistribution of 99mTc-AP39 in F9 Tumor–Bearing Mice

Biodistribution time (h)
Tissue0.2513524
Uptake (%ID/g)
 Spleen5.1 ± 0.72.0 ± 0.30.7 ± 0.20.6 ± 0.10.2 ± 0.0
 Liver5.1 ± 0.22.5 ± 0.31.1 ± 0.21.1 ± 0.20.3 ± 0.0
 Kidneys48.2 ± 4.221.8 ± 2.58.6 ± 0.67.9 ± 0.42.6 ± 0.4
 Lung6.9 ± 1.73.1 ± 0.21.2 ± 0.01.1 ± 0.20.8 ± 1.0
 Bone*2.8 ± 0.92.3 ± 0.31.6 ± 0.21.7 ± 0.10.8 ± 0.2
 Heart4.1 ± 1.31.8 ± 0.20.7 ± 0.20.4 ± 0.00.2 ± 0.0
 Brain0.4 ± 0.00.1 ± 0.00.1 ± 0.0NDND
 Thyroid3.4 ± 0.62.0 ± 0.21.3 ± 0.11.3 ± 0.70.8 ± 0.4
 Muscle*0.8 ± 0.10.6 ± 0.00.6 ± 0.20.2 ± 0.00.1 ± 0.0
 Stomach†1.7 ± 0.11.4 ± 0.01.1 ± 0.11.0 ± 0.00.4 ± 0.1
 Intestine‡1.6 ± 0.11.4 ± 0.01.3 ± 0.21.6 ± 0.50.3 ± 0.0
 Uterus2.5 ± 0.82.0 ± 0.51.4 ± 0.72.8 ± 1.21.3 ± 0.7
 Ovaries13.0 ± 1.87.6 ± 2.24.3 ± 1.42.7 ± 0.90.9 ± 0.1
 Tumor5.2 ± 2.56.1 ± 2.08.3 ± 3.28.7 ± 5.52.8 ± 1.4
 Blood14.4 ± 0.93.9 ± 0.81.3 ± 0.11.0 ± 0.10.2 ± 0.0
Excretion (%ID)
 Urine22.7 ± 3.946.7 ± 4.448.8 ± 6.752.5 ± 2.064.5 ± 6.5
 FecesNDND0.4 ± 0.10.6 ± 0.54.8 ± 1.0
Tumor/tissue ratio
 T/spleen1.0 ± 0.33.1 ± 0.612.4 ± 7.314.8 ± 11.411.5 ± 4.5
 T/liver1.0 ± 0.42.4 ± 0.57.8 ± 4.08.3 ± 6.28.1 ± 3.6
 T/kidneys0.1 ± 0.00.3 ± 0.11.0 ± 0.41.1 ± 0.81.0 ± 0.4
 T/lung0.8 ± 0.52.0 ± 0.76.8 ± 2.68.3 ± 6.57.5 ± 5.9
 T/muscle6.8 ± 3.410.5 ± 3.213.6 ± 2.638.5 ± 28.925.3 ± 11.2
 T/blood0.4 ± 0.21.6 ± 0.26.4 ± 2.99.0 ± 6.517.2 ± 6.8
 T/intestine3.3 ± 1.34.3 ± 1.36.9 ± 3.66.9 ± 6.98.9 ± 3.7

  • ↵* Tissue aliquot only.

  • ↵† Without content.

  • ↵‡ With content.

  • ND = not detectable; T = tumor.

  • All data are presented as mean ± SD (n = 3).