Non-CB1 CNS Drugs for Blocking Studies in Mice
| Non-CB1 drug | Target receptor | Dose (mg/kg) | Time of administration before radiotracer (min) |
|---|---|---|---|
| Naltrindole | Selective δ-opiod antagonist | 3 | 5 |
| Naloxone | μ-, κ-, δ-opioid antagonist | 1 | 15 |
| SCH23390 | D1- and D5-antagonist and 5-HT1C/2C agonist | 1 | 5 |
| Spiperone | D2-like and 5-HT2A receptor antagonist | 1 | 5 |
| Ketanserin | 5-HT2/5-HT2C antagonist | 2 | 5 |
| Cytisine | α4β2-nAChR agonist | 2 | 15 |
5-HT = 5-hydroxytryptamine (serotonin); nAChR = nicotinic acetylcholine receptor.