TABLE 2

ROIs Derived from microPET Images of Animals Given Pretargeted ¹²⁴I-IMP-325 or ¹²⁴I-Humanized Anti-CEA Fab′

	Activity/volume (mean ± SD)		Tumor/ kidney ratio
Animal/time	Tumor	Kidney	Tumor/ kidney ratio
Pretargeted ¹²⁴I-IMP-325
Animal 1 (tumor, 0.448 g)
1.9 h	2.58 ± 1.09	1.11 ± 0.24	2.3
6.3 h	2.44 ± 1.24	0.92 ± 0.23	2.6
24 h	2.44 ± 1.20	0.55 ± 0.24	4.4
Animal 2 (tumor, 0.483 g)
2.7 h	1.82 ± 0.67	0.89 ± 0.38	2.0
6.4 h	1.67 ± 0.68	0.71 ± 0.26	2.4
25 h	1.85 ± 0.64	0.44 ± 0.16	4.2
Animal 3 (tumor, 0.285 g)
2.1 h	2.06 ± 0.75	0.70 ± 0.25	2.9
5.8 h	1.89 ± 0.76	0.44 ± 0.19	4.3
25 h	1.90 ± 0.70	0.29 ± 0.08	6.6
¹²⁴I-Anti-CEA Fab′
Animal 1 (tumor, 0.596 g)
2.1 h	1.77 ± 0.41	11.28 ± 2.86	0.16
6.5 h	1.76 ± 0.43	3.85 ± 0.53	0.46
26 h	0.49 ± 0.09	0.09 ± 0.05	5.44
Animal 2 (tumor, 0.173 g)
1.8 h	1.07 ± 0.49	8.14 ± 2.73	0.10
6.5 h	0.71 ± 0.33	1.68 ± 0.48	0.42
27 h	0.17 ± 0.09	0.10 ± 0.05	1.7
Animal 3 (tumor, 0.280 g)
2.9 h	1.84 ± 0.58	10.33 ± 3.22	0.18
6.6 h	1.03 ± 0.39	1.42 ± 0.70	0.73
27 h	0.36 ± 0.12	0.09 ± 0.04	4.00