TABLE 2

ROIs Derived from microPET Images of Animals Given Pretargeted 124I-IMP-325 or 124I-Humanized Anti-CEA Fab′

Activity/volume (mean ± SD)Tumor/ kidney ratio
Animal/timeTumorKidney
Pretargeted 124I-IMP-325
Animal 1 (tumor, 0.448 g)
 1.9 h2.58 ± 1.091.11 ± 0.242.3
 6.3 h2.44 ± 1.240.92 ± 0.232.6
 24 h2.44 ± 1.200.55 ± 0.244.4
Animal 2 (tumor, 0.483 g)
 2.7 h1.82 ± 0.670.89 ± 0.382.0
 6.4 h1.67 ± 0.680.71 ± 0.262.4
 25 h1.85 ± 0.640.44 ± 0.164.2
Animal 3 (tumor, 0.285 g)
 2.1 h2.06 ± 0.750.70 ± 0.252.9
 5.8 h1.89 ± 0.760.44 ± 0.194.3
 25 h1.90 ± 0.700.29 ± 0.086.6
124I-Anti-CEA Fab′
Animal 1 (tumor, 0.596 g)
 2.1 h1.77 ± 0.4111.28 ± 2.860.16
 6.5 h1.76 ± 0.433.85 ± 0.530.46
 26 h0.49 ± 0.090.09 ± 0.055.44
Animal 2 (tumor, 0.173 g)
 1.8 h1.07 ± 0.498.14 ± 2.730.10
 6.5 h0.71 ± 0.331.68 ± 0.480.42
 27 h0.17 ± 0.090.10 ± 0.051.7
Animal 3 (tumor, 0.280 g)
 2.9 h1.84 ± 0.5810.33 ± 3.220.18
 6.6 h1.03 ± 0.391.42 ± 0.700.73
 27 h0.36 ± 0.120.09 ± 0.044.00