TABLE 1

Tissue Uptake and Targeting Ratios for Pretargeted or Nonpretargeted ¹³¹I-IMP-325 and Pretargeted ¹¹¹In-IMP-288

	%ID/organ
	Pretargeted ¹³¹I-IMP-325			¹³¹I-Peptide alone, 4 h (n = 2)	Pretargeted ¹¹¹In-IMP-288
Tumor or organ	1 h (n = 5)	4 h (n = 5)	24 h (n = 3)	¹³¹I-Peptide alone, 4 h (n = 2)	1 h (n = 5)	24 h (n = 3)
Tumor	15.1 ± 4.6^*	13.9 ± 3.5	10.5 ± 2.6	0.19, 0.47	18.7 ± 9.6	13.6 ± 2.6
Tumor	1.10 ± 0.26^†	1.15 ± 0.35	1.52 ± 0.65	1.1, 2.7	1.07 ± 0.55	1.40 ± 0.42
Liver	0.48 ± 0.06	0.32 ± 0.04	0.21 ± 0.02	0.15, 0.18	0.36 ± 0.09	0.18 ± 0.02
1.22 ± 0.17	(34.6 ± 5.9)^‡	(39.8 ± 2.9)	(43.0 ± 9.2)	0.15, 0.18	(63.6 ± 24.8)	(61.9 ± 9.8)
Spleen	0.04 ± 0.00	0.03 ± 0.00	0.01 ± 0.00	0.012, 0.013	0.03 ± 0.01	0.01 ± 0.00
0.10 ± 0.02	(36.4 ± 4.3)	(47.2 ± 6.9)	(49.4 ± 18.6)		(65.5 ± 22.3)	(83.9 ± 15.2)
Kidney	0.67 ± 0.24	0.37 ± 0.06	0.24 ± 0.02	0.37, 0.35	0.48 ± 0.07	0.21 ± 0.02
0.15 ± 0.02	(3.4 ± 1.3)	(4.8 ± 0.2)	(4.6 ± 0.9)		(6.1 ± 0.9)	(6.7 ± 1.0)
Lungs	0.13 ± 0.01	0.05 ± 0.01	0.01 ± 0.00	0.02, 0.02	0.11 ± 0.03	0.02 ± 0.00
0.17 ± 0.03	(17.8 ± 3.3)	(33.0 ± 1.9)	(70.5 ± 20.6)		(40.5 ± 3.7)	(78.5 ± 9.3)
Blood	1.48 ± 0.16^§	0.44 ± 0.06	0.04 ± 0.01	0.30, 0.32	0.96 ± 0.51	0.03 ± 0.01
22.7 ± 1.6^‖	(15.5 ± 2.6)	(44.3 ± 3.9)	(280 ± 10)		(40.3 ± 24.0)	(517 ± 42)
Stomach^¶	1.0 ± 0.1	0.80 ± 0.11	0.05 ± 0.01	0.74, 0.77	0.07 ± 0.03	0.03 ± 0.02
0.4 ± 0.05	(5.7 ± 1.6)	(4.5 ± 0.8)	(56.8 ± 16.1)		(188 ± 200)	(179 ± 134)

↵* Values represent mean ± SD, except for peptide alone, where individual animal data are provided.
↵† Italicized values are tissue weights in grams; tumor weights for each group are given, whereas representative tissue weights are provided from group of animals necropsied at 1 h.
↵‡ Tumor-to-nontumor ratios based on %ID/g.
↵§ Total blood volume estimated as 7.4% of body weight.
↵‖ Average body weight of animals necropsied at 1 h.
↵¶ Includes contents.