Effect of Polymer Conjugation on Mean T/B for αvβ3 Active RGD4C Peptide and Control RGE4C Peptide
| Biodistribution | DU145 | PC-3 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HPMA-RGD4C | RGD4C-DPK | HPMA-RGE4C | RGE4C-DPK | HPMA-RGD4C | RGD4C-DPK | HPMA-RGE4C | RGE4C-DPK | |||||||
| Blood | 18.03 | 30.28 | 5.46 | 3.25 | 18.29 | 35.94 | 4.36 | 3.99 | ||||||
| Heart | 37.10 | 7.62 | 7.82 | 0.81 | 43.80 | 8.41 | 9.32 | 0.99 | ||||||
| Lung | 29.97 | 3.28 | 5.98 | 0.35 | 40.56 | 3.84 | 5.94 | 0.26 | ||||||
| Liver | 1.05 | 0.25 | 0.32 | 0.03 | 1.29 | 0.37 | 0.38 | 0.04 | ||||||
| Spleen | 1.08 | 0.49 | 0.30 | 0.05 | 1.80 | 0.73 | 0.56 | 0.07 | ||||||
| Kidney | 0.51 | 0.25 | 0.12 | 0.02 | 0.58 | 0.36 | 0.15 | 0.03 | ||||||
| Muscle | 166.62 | 10.64 | 9.00 | 1.15 | 89.63 | 22.43 | 12.81 | 1.89 | ||||||