TABLE 1

18F-FDG Biodistribution, Plasma Glucose, and Insulin Levels Obtained With or Without Anesthesia and After 4 or 20 Hours of Fasting in LLC-Bearing Mice

Tissue4 h of Fasting20 h of Fasting
Control (n = 7)Xy/Ke (n = 7)Pentobarbital (n = 6)Control (n = 4)Xy/Ke (n = 4)Pentobarbital (n = 4)
Biodistribution
    Blood1.15 ± 0.626.78 ± 0.91†2.50 ± 0.84†2.45 ± 0.325.51 ± 2.18†4.95 ± 0.85†
    Heart4.71 ± 1.772.31 ± 1.27‡2.76 ± 0.54†2.94 ± 0.723.06 ± 0.662.41 ± 0.28
    Lung4.22 ± 1.834.65 ± 1.733.65 ± 0.678.17 ± 1.119.32 ± 0.618.62 ± 1.33
    Liver2.56 ± 3.056.61 ± 1.73‡2.83 ± 1.102.93 ± 0.215.73 ± 2.24†5.34 ± 1.05
    Spleen2.93 ± 0.854.33 ± 2.003.52 ± 0.777.89 ± 0.678.89 ± 1.338.59 ± 1.07
    Kidney1.54 ± 0.6512.17 ± 4.96†3.54 ± 1.583.04 ± 0.408.27 ± 3.29†7.17 ± 1.84
    Muscle4.49 ± 2.401.08 ± 0.43‡0.83 ± 0.15†3.95 ± 4.041.19 ± 0.401.00 ± 0.24
    Tumor6.69 ± 2.915.63 ± 2.566.61 ± 1.2823.61 ± 2.2430.38 ± 2.57†26.47 ± 3.32
Plasma glucose (g/mL)230.1 ± 31.2418.8 ± 113.5‡195.9 ± 44.675.7 ± 8.075.3 ± 10.669.3 ± 12.3
Plasma insulin (μIU/ml)29.6 ± 18.910.1 ± 0.9†49.6 ± 29.58.1 ± 0.58.1 ± 0.56.7 ± 1.6

  • *P < 0.001 compared with controls.

  • ↵† P < 0.05 compared with controls.

  • ↵‡ P < 0.01 compared with controls.

  • Biodistribution values are given as mean ± SD of %ID/g of tissue. P values are significance of difference compared with respective controls.