PET | Young | Old | P value |
---|---|---|---|
Wild-type | 65.0 ± 16.9 | 82.6 ± 20.9 | 0.185 (NS) |
Transgenic | 73.8 ± 15.0 | 129.3 ± 15.3 | <0.001 (S) |
P value | 0.413 (NS) | 0.004 (S) |
MRI | Young*† | Old*† | P value*† |
---|---|---|---|
Wild-type | 94.7 ± 14.6 | 106.2 ± 12.3 | 0.214 (NS) |
111.3 ± 16.0† | 122.8 ± 12.3† | 0.27† (NS) | |
Transgenic | 114.7 ± 15.2 | 160.5 ± 25.7 | 0.012 (S) |
132.3 ± 15.8† | 174.6 ± 25.5† | 0.014† (S) | |
P value | 0.067 (NS) | 0.006 (S) | |
0.071† (NS) | 0.004† (S) |
↵* First row of results for equal fractional contributions of end-diastolic or end-systolic volumes in definition of LV-VIMRI (xED = xES = 0.5).
↵† Denotes values with unequal fractional contributions (xED = 0.8, xES = 0.2).
NS = nonsignificant results; S = significant results.
Mean values of midmyocardial volumes (in μL) ± SDs for all 4 groups of animals (young—old, wild-type—transgenic) are presented together with t-test results (P values). Results are presented separately for PET and MRI measurement techniques.