Summary of SURs Reported in Literature Using 123I-ADAM SPECT in Healthy Volunteers
| Reference | n | Age (y) | Scan acquisition interval (min after injection) | 123I-ADAM uptake value | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Midbrain | Thalamus | Striatum | Mesial temporal | Cortex | ||||||||
| 9 | 7 | 22–54 | 210–270 | 1.95 ± 0.3 | NA | 1.11 ± 0.07 | 1.27 ± 0.1 | NA | ||||
| (0.95*) | (0.11*) | (0.27*) | ||||||||||
| 18 | 6 | 30–42 | 150–210 | 2.1–2.7 | 2.2 (1.2*) | 2.0 (1.0*) | NA | 1.3 (0.3*) | ||||
| (1.1–1.7*) | ||||||||||||
| 17 | 9 | 23–55 | 300 | 1.61 ± 0.35 | NA | NA | NA | NA | ||||
| 19 | 12 | 22–62 | 210† | 1.21 ± 0.12 | NA | NA | NA | NA | ||||
| This study | 10‡ | 28–65 | 240–360 | 1.21 ± 0.24 | 0.86 ± 0.20 | 0.61 ± 0.18 | 0.55 ± 0.12 | ≤0.21 | ||||
↵* Values in parentheses are calculated as ([target/cerebellum ratio] − 1) for those articles originally reporting target/cerebellum ratios, to allow comparison with SURs (target − cerebellum/cerebellum).
↵† No decline of SUR up to last scan acquired at 300 min after injection.
↵‡ SUR calculated from 20 SPECT examinations performed on 10 subjects.
NA = not available.