Results of 18F-FDG PET, CT/MRI, and Their Visual Correlation in 124 Patients with Oral Cavity SCC
| Neck level | FN | TP | TN | FP | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|---|
| Level I | |||||||||
| CT/MRI | 21 | 29 | 93 | 8 | 58.0 (43.2–71.8) | 92.1 (85.0–96.5) | 80.8 (73.6–86.7) | 78.4 (61.8–90.2) | 81.6 (73.2–88.2) |
| 18F-FDG PET | 10 | 40 | 91 | 10 | 80.0 (66.3–90.0) | 90.1 (82.5–95.1) | 86.8 (80.3–91.7) | 80.0 (66.3–90.0) | 90.1 (82.5–95.1) |
| CT/MRI + 18F-FDG PET | 9 | 41 | 94 | 7 | 82.0 (68.6–91.4) | 93.1 (86.2–97.2) | 89.4 (83.4–93.8) | 85.4 (72.2–93.9) | 91.3 (84.1–95.9) |
| Level II | |||||||||
| CT/MRI | 11 | 16 | 111 | 12 | 59.3 (38.8–77.6) | 90.2 (83.6–94.9) | 84.7 (77.9–90.0) | 57.1 (37.2–75.5) | 91.0 (84.4–95.4) |
| 18F-FDG PET | 5 | 22 | 109 | 14 | 81.5 (61.9–93.7) | 88.6 (81.6–93.6) | 87.3 (80.9–92.2) | 61.1 (43.5–76.9) | 95.6 (90.1–98.6) |
| CT/MRI + 18F-FDG PET | 4 | 23 | 110 | 13 | 85.2 (66.3–95.8) | 89.4 (82.6–94.3) | 88.7 (82.5–93.3) | 63.9 (46.2–79.2) | 96.5 (91.3–99.0) |
| Level III | |||||||||
| CT/MRI | 9 | 5 | 133 | 2 | 35.7 (12.8–64.9) | 98.5 (94.8–99.8) | 92.6 (87.2–96.3) | 71.4 (29.0–96.3) | 93.7 (88.3–97.1) |
| 18F-FDG PET | 7 | 7 | 131 | 4 | 50.0 (23.0–77.0) | 97.0 (92.6–99.2) | 92.6 (87.2–96.3) | 63.6 (30.8–89.1) | 94.9 (89.8–97.9) |
| CT/MRI + 18F-FDG PET | 6 | 8 | 133 | 2 | 57.1 (28.9–82.3) | 98.5 (94.8–99.8) | 94.6 (89.7–97.7) | 80.0 (44.4–97.5) | 95.7 (90.8–98.4) |
| Level IV | |||||||||
| CT/MRI | 4 | 0 | 21 | 0 | 0 | 100 | 84.0 (63.9–95.5) | — | 84.0 (63.9–95.5) |
| 18F-FDG PET | 2 | 2 | 21 | 0 | 50.0 (6.8–93.2) | 100 | 92.0 (74.0–99.0) | 100 | 91.3 (72.0–98.9) |
| CT/MRI + 18F-FDG PET | 2 | 2 | 21 | 0 | 50.0 (6.8–93.2) | 100 | 92.0 (74.0–99.0) | 100 | 91.3 (72.0–98.9) |
| Level V | |||||||||
| CT/MRI | 0 | 0 | 18 | 0 | — | 100 | 100 | — | 100 |
| 18F-FDG PET | 0 | 0 | 18 | 0 | — | 100 | 100 | — | 100 |
| CT/MRI + 18F-FDG PET | 0 | 0 | 18 | 0 | — | 100 | 100 | — | 100 |
| Total | |||||||||
| CT/MRI | 45 | 50 | 376 | 22 | 52.6 (42.1–63.0) | 94.5 (91.8–96.5) | 86.4 (83.1–89.3) | 69.4 (57.5–79.8) | 89.3 (86.0–92.1) |
| 18F-FDG PET | 24 | 71 | 370 | 28 | 74.7 (64.8–83.1) | 93.0 (90.0–95.3) | 89.5 (86.4–92.0) | 71.7 (61.8–80.3) | 93.9 (91.1–96.1) |
| CT/MRI + 18F-FDG PET | 21 | 74 | 376 | 22 | 77.9 (68.2–85.8) | 94.5 (91.8–96.5) | 91.3 (88.4–93.6) | 77.1 (67.4–85.0) | 94.7 (92.0–96.7) |
FN = false-negative; TP = true-positive; TN = true-negative; FP = false-positive; PPV = positive predictive value; NPV = negative predictive value.
Ranges in parentheses are 95% confidence intervals.