TABLE 2

Summary of BPs for Benzamide Radioligands ¹⁸F-DMFP, ¹¹C-RAC, and ¹⁸F-FP in Thalamus and Entire Striatum Calculated Using Several Metabolite-Corrected Arterial Input Models and Reference Tissue Models

BP	Comparison	Thalamus					Striatum
BP	Comparison			¹⁸F-DMFP	¹¹C-RAC	¹⁸F-FP	¹⁸F-DMFP	¹¹C-RAC	¹⁸F-FP
2-Tissue compartment	VOI	0.26 ± 0.15	0.62 ± 0.09	3.27 ± 1.16	1.93 ± 0.58	4.00 ± 0.84	34.45 ± 5.87
Logan plot arterial	Voxel	0.20 ± 0.10	0.46 ± 0.13	2.26 ± 0.53	2.20 ± 0.37	3.12 ± 0.25	26.60 ± 5.27
	VOI	0.23 ± 0.12	0.47 ± 0.08	1.96 ± 0.54	2.21 ± 0.32	3.16 ± 0.19	26.32 ± 5.72
Logan plot cerebellum	Voxel	0.21 ± 0.11	0.40 ± 0.13	2.11 ± 0.51	2.20 ± 0.35	3.02 ± 0.19	23.68 ± 4.81
	VOI	0.24 ± 0.13	0.47 ± 0.07	1.88 ± 0.53	2.19 ± 0.31	3.14 ± 0.20	23.03 ± 4.80
SRTM	Voxel	0.22 ± 0.11	0.49 ± 0.13	2.17 ± 0.45	2.35 ± 0.36	3.16 ± 0.21	21.72 ± 4.10
	VOI	0.24 ± 0.11	0.43 ± 0.13	1.90 ± 0.55	2.29 ± 0.32	3.17 ± 0.21	23.26 ± 4.89
LRSC	Voxel	0.31 ± 0.17	0.51 ± 0.05	2.23 ± 0.51	2.47 ± 0.34	3.26 ± 0.23	22.49 ± 4.04
Simple ratio	Voxel	1.21 ± 0.13	1.50 ± 0.08	3.83 ± 1.08	3.74 ± 0.54	5.10 ± 0.38	30.06 ± 7.47

First, a 2-tissue compartment model was fitted to TACs in VOIs defined for thalamus and striatum. An arterial input Logan analysis, reference tissue Logan analysis, conventional simplified reference tissue method (SRTM), and SRTM with linear regression and spatial constraint (LRSC) were likewise used to calculate BPs in time–radioactivity curves from thalamus and striatum VOIs; in addition, mean voxelwise estimates in parametric maps were calculated for the same VOIs. Finally, the simple ratios of VOI activity to cerebellum activity at steady state are reported. Each estimate is mean ± SD of 16 separate determinations in the case of ¹⁸F-DMFP, 6 in the case of ¹¹C-RAC, and 10 in the case of ¹⁸F-FP.