TABLE 2

Plasma Clearance Kinetics*: 111In-J591 vs. 177Lu-J591

Pharmcokinetic parameterBiexponentialMonoexponential
111In-J591177Lu-J591111In-J591177Lu-J591
t1/2 (h)32.3 ± 8.139.1 ± 13.3
    α2.37 ± 1.942.04 ± 1.96
    β44.20 ± 13.943.60 ± 16.1
AUC1.19 ± 0.441.49 ± 0.631.08 ± 0.41.42 ± 0.60
Cmax (%ID/mL)0.026 ± 0.0010.027 ± 0.0050.023 ± 0.0050.025 ± 0.005
Vd (mL) at t04,042 ± 8633,952 ± 1,0724,467 ± 8114,156 ± 858
Clearance (mL/h)94 ± 3484 ± 4698 ± 4388 ± 47
  • * Difference between 111In and 177Lu data was statistically insignificant (P > 0.05).

  • Last time point with 111In was 146 ± 13 h and with 177Lu was 320 ± 15 h.

  • AUC = area under the curve; Cmax = maximum concentration in plasma; Vd = volume of distribution; t0 = time zero.