Pharmcokinetic parameter | Biexponential | Monoexponential | ||||
---|---|---|---|---|---|---|
111In-J591† | 177Lu-J591† | 111In-J591 | 177Lu-J591 | |||
t1/2 (h) | 32.3 ± 8.1 | 39.1 ± 13.3 | ||||
α | 2.37 ± 1.94 | 2.04 ± 1.96 | ||||
β | 44.20 ± 13.9 | 43.60 ± 16.1 | ||||
AUC | 1.19 ± 0.44 | 1.49 ± 0.63 | 1.08 ± 0.4 | 1.42 ± 0.60 | ||
Cmax (%ID/mL) | 0.026 ± 0.001 | 0.027 ± 0.005 | 0.023 ± 0.005 | 0.025 ± 0.005 | ||
Vd (mL) at t0 | 4,042 ± 863 | 3,952 ± 1,072 | 4,467 ± 811 | 4,156 ± 858 | ||
Clearance (mL/h) | 94 ± 34 | 84 ± 46 | 98 ± 43 | 88 ± 47 |