Patient no. | Dosage of amisulpride (mg/d) | Dosage of amisulpride (mg/kg of body weight/d) | Plasma concentration of amisulpride (μg/L) | D2 receptor occupancy* (%) |
---|---|---|---|---|
1 | 50 | 0.81 | 77 | 41.9 |
2 | 100 | 1.55 | 27 | 50.1 |
3 | 100 | 1.74 | 128 | 60.3 |
4 | 150 | 1.70 | 120 | 58.3 |
5 | 200 | 2.67 | 108 | 75.9 |
6 | 200 | 2.95 | 104 | 65.5 |
7 | 300 | 3.28 | — | 67.6 |
8 | 300 | 3.79 | 84 | 66.5 |
9 | 300 | 3.80 | 145 | 78.9 |
10 | 300 | 4.06 | 118 | 71.9 |
11 | 300 | 4.14 | 55 | 68.6 |
12 | 300 | 4.17 | 312 | 82.9 |
13 | 300 | 4.25 | 82 | 65.0 |
14 | 300 | 5.17 | 385 | 85.9 |
15 | 400 | 4.65 | 88 | 51.3 |
16 | 400 | 5.01 | 179 | 81.7 |
17 | 400 | 5.70 | 184 | 77.0 |
18 | 500 | 6.75 | 421 | 81.7 |
19 | 500 | 8.65 | 114 | 79.5 |
20 | 600 | 6.32 | 177 | 92.1 |
21 | 600 | 8.05 | 121 | 66.1 |
22 | 600 | 9.69 | 219 | 79.4 |
23 | 800 | 6.58 | 169 | 77.8 |
24 | 800 | 8.51 | 64 | 87.8 |
25 | 800 | 10.13 | 223 | 60.6 |
26 | 800 | 10.61 | 263 | 87.4 |
27 | 800 | 10.81 | 518 | 100.0 |
28 | 800 | 11.51 | 261 | 70.5 |
29 | 1,200 | 19.20 | 910 | 93.4 |
↵* (SBcontrol − SBpatient)/SBcontrol.