Biodistribution of [99mTc]Demobesin 1 in Double (Rat AR4-2J and Human PC-3) Tumor-Bearing Athymic Mice
| Organ | Time after injection | ||||
|---|---|---|---|---|---|
| 1 h | 4 h | 24 h | |||
| Blood | 1.20 ± 0.27 | 0.29 ± 0.10 | 0.09 ± 0.09 | ||
| Liver | 5.92 ± 1.0 | 4.71 ± 1.1 | 0.59 ± 0.10 | ||
| Heart | 0.91 ± 0.18 | 0.27 ± 0.17 | 0.08 ± 0.02 | ||
| Kidneys | 8.10 ± 1.34 | 5.76 ± 1.95 | 0.49 ± 0.14 | ||
| Stomach | 3.91 ± 0.54 | 2.79 ± 0.55 | 0.18 ± 0.10 | ||
| Intestine | 11.99 ± 0.87 | 12.18 ± 1.60 | 0.59 ± 0.11 | ||
| Spleen | 1.00 ± 0.29 | 0.41 ± 0.12 | 0.12 ± 0.02 | ||
| Muscle | 0.50 ± 0.36 | 0.09 ± 0.03 | 0.06 ± 0.02 | ||
| Lung | 1.66 ± 0.36 | 0.41 ± 0.07 | 0.67 ± 0.99 | ||
| Pancreas | 82.30 ± 9.46 | 35.28 ± 10.66 | 0.76 ± 0.25 | ||
| AR4-2J tumor | 4.42 ± 0.91 | 2.78 ± 0.67 | 0.71 ± 0.09 | ||
| PC-3 tumor | 13.45 ± 3.04 | 9.42 ± 0.65 | 2.17 ± 0.63 | ||
| Organ | Blocking at 4 h after injection* | ||
|---|---|---|---|
| 100 μg | 250 μg | ||
| Stomach | 2.82 ± 1.15 | 2.09 ± 0.50 | |
| Intestine | 7.77 ± 1.11 | 5.55 ± 0.72 | |
| Pancreas | 7.20 ± 1.12 | 3.78 ± 1.37 | |
| AR4-2J tumor | 3.16 ± 0.60 | 1.60 ± 0.09 | |
| PC-3 tumor | 4.75 ± 0.91 | 2.27 ± 0.32 | |
↵* Blocking by coinjection of 100 or 250 μg [Tyr4]BB.