Biodistribution of [111In]Z-070 in Double (Rat AR4-2J and Human PC-3) Tumor-Bearing Athymic Mice
| Organ | Time after injection | ||||
|---|---|---|---|---|---|
| 1 h | 4 h | 24 h | |||
| Blood | 0.78 ± 0.25 | 0.38 ± 0.27 | 0.40 ± 0.50 | ||
| Liver | 0.95 ± 0.19 | 0.55 ± 0.07 | 0.28 ± 0.04 | ||
| Heart | 0.84 ± 0.25 | 0.49 ± 0.12 | 0.30 ± 0.01 | ||
| Kidneys | 9.37 ± 3.80 | 5.49 ± 1.99 | 0.78 ± 0.18 | ||
| Stomach | 1.52 ± 0.24 | 0.68 ± 0.13 | 0.16 ± 0.08 | ||
| Intestine | 6.41 ± 0.59 | 6.78 ± 1.49 | 1.30 ± 0.11 | ||
| Spleen | 1.21 ± 0.38 | 1.07 ± 0.31 | 0.28 ± 0.04 | ||
| Muscle | 0.56 ± 0.19 | 0.33 ± 0.03 | 0.33 ± 0.08 | ||
| Lung | 1.23 ± 0.38 | 0.38 ± 0.04 | 0.48 ± 0.23 | ||
| Pancreas | 43.04 ± 13.44 | 25.36 ± 1.43 | 2.16 ± 0.68 | ||
| AR4-2J tumor | 3.24 ± 0.72 | 2.72 ± 0.56 | 1.87 ± 0.37 | ||
| PC-3 tumor | 4.67 ± 1.60 | 2.57 ± 0.56 | 1.19 ± 0.27 | ||
| Organ | Blocking at 4 h after injection* | ||
|---|---|---|---|
| 100 μg | 250 μg | ||
| Stomach | 1.17 ± 0.56 | 1.37 ± 0.47 | |
| Intestine | 1.40 ± 0.21 | 1.53 ± 0.36 | |
| Pancreas | 1.44 ± 0.13 | 1.14 ± 0.13 | |
| AR4-2J tumor | 1.88 ± 0.59 | 1.22 ± 0.22 | |
| PC-3 tumor | 3.00 ± 1.26 | 1.85 ± 0.12 | |
↵* Blocking by coinjection of 100 or 250 μg [Tyr4]BB.