TABLE 2

Tissue Distributions of α-MSH Analogs 4, 24, and 48 Hours After Injection

α-MSH analog	Time (h) *	%ID/g in the following tissue ^†:
α-MSH analog	Time (h) *			Blood	Tumor	Stomach	Kidney	Liver	Spleen	Lung	Small intestine	Pancreas	Heart	Bone	Muscle
DOTA-NAPamide	4	0.09 ± 0.02	7.77 ± 0.35	0.09 ± 0.01	4.77 ± 0.26	0.34 ± 0.05	0.14 ± 0.01	0.08 ± 0.01	0.07 ± 0.01	0.04 ± 0.00	0.05 ± 0.01	0.11 ± 0.02	0.05 ± 0.01
	24	0.02 ± 0.00	2.32 ± 0.15	0.12 ± 0.02	2.41 ± 0.20	0.31 ± 0.02	0.11 ± 0.01	0.05 ± 0.01	0.08 ± 0.01	0.03 ± 0.00	0.03 ± 0.00	0.14 ± 0.02	0.02 ± 0.00
	48	0.00 ± 0.00	1.41 ± 0.12	0.11 ± 0.05	1.55 ± 0.07	0.27 ± 0.02	0.10 ± 0.01	0.03 ± 0.00	0.05 ± 0.01	0.02 ± 0.00	0.01 ± 0.00	0.05 ± 0.01	0.01 ± 0.00
III	4	0.01 ± 0.00 ^‡	2.82 ± 0.25 ^‡	0.08 ± 0.03	4.10 ± 0.32	0.24 ± 0.01	0.03 ± 0.00 ^‡	0.02 ± 0.00 ^‡	0.03 ± 0.01	0.01 ± 0.00	0.01 ± 0.00 ^‡	0.03 ± 0.00 ^‡	0.01 ± 0.00
	24	0.00 ± 0.00 ^‡	0.88 ± 0.08 ^‡	0.11 ± 0.05	1.67 ± 0.09	0.19 ± 0.01 ^‡	0.03 ± 0.00 ^‡	0.02 ± 0.00 ^‡	0.03 ± 0.01 ^‡	0.01 ± 0.00 ^‡	0.01 ± 0.00 ^‡	0.03 ± 0.00 ^‡	0.01 ± 0.00
	48	0.00 ± 0.00	0.54 ± 0.06 ^‡	0.04 ± 0.02	1.11 ± 0.11	0.13 ± 0.01 ^‡	0.06 ± 0.00 ^‡	0.03 ± 0.00	0.03 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.04 ± 0.00	0.01 ± 0.00 ^‡
IV	4	0.03 ± 0.00 ^‡	5.85 ± 0.38 ^‡	0.19 ± 0.07	12.1 ± 0.59 ^‡	0.43 ± 0.01	0.15 ± 0.10	0.10 ± 0.01	0.13 ± 0.05	0.03 ± 0.00	0.03 ± 0.00	0.15 ± 0.03	0.02 ± 0.00
	24	0.01 ± 0.00	1.99 ± 0.03	0.17 ± 0.02	9.32 ± 0.57 ^‡	0.31 ± 0.01	0.12 ± 0.00	0.05 ± 0.01	0.05 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.10 ± 0.01	0.01 ± 0.00 ^‡
	48	0.01 ± 0.00 ^‡	0.95 ± 0.14 ^‡	0.12 ± 0.01	3.68 ± 0.79 ^‡	0.21 ± 0.01 ^‡	0.15 ± 0.01 ^‡	0.07 ± 0.02 ^‡	0.05 ± 0.00	0.03 ± 0.00 ^‡	0.04 ± 0.00 ^‡	0.10 ± 0.00 ^‡	0.02 ± 0.00 ^‡
V	4	0.02 ± 0.00 ^‡	3.97 ± 0.24 ^‡	0.19 ± 0.08	3.76 ± 0.08	0.12 ± 0.00 ^‡	0.08 ± 0.00 ^‡	0.07 ± 0.01	0.08 ± 0.03	0.02 ± 0.00	0.02 ± 0.00	0.06 ± 0.00	0.03 ± 0.01
	24	0.01 ± 0.00	1.71 ± 0.16 ^‡	0.10 ± 0.02	2.22 ± 0.07	0.08 ± 0.00 ^‡	0.08 ± 0.00 ^‡	0.03 ± 0.00	0.04 ± 0.00	0.02 ± 0.00	0.02 ± 0.00	0.05 ± 0.00 ^‡	0.02 ± 0.00
	48	0.01 ± 0.00 ^‡	0.75 ± 0.11 ^‡	0.05 ± 0.00	1.46 ± 0.11	0.06 ± 0.00 ^‡	0.09 ± 0.01	0.03 ± 0.00	0.03 ± 0.00	0.02 ± 0.00	0.03 ± 0.00 ^‡	0.05 ± 0.00	0.02 ± 0.00 ^‡
VI	4	0.01 ± 0.00 ^‡	0.65 ± 0.05 ^‡	0.18 ± 0.07	3.14 ± 0.25 ^‡	0.10 ± 0.01 ^‡	0.08 ± 0.00 ^‡	0.06 ± 0.00	0.05 ± 0.02	0.02 ± 0.00	0.03 ± 0.00	0.07 ± 0.00	0.02 ± 0.00
	24	0.00 ± 0.00 ^‡	0.23 ± 0.01 ^‡	0.04 ± 0.01	1.98 ± 0.25	0.05 ± 0.00 ^‡	0.07 ± 0.01 ^‡	0.04 ± 0.01	0.03 ± 0.00	0.02 ± 0.00	0.03 ± 0.00	0.05 ± 0.01 ^‡	0.02 ± 0.00
	48	0.00 ± 0.00	0.14 ± 0.01 ^‡	0.05 ± 0.02	1.07 ± 0.10	0.04 ± 0.00 ^‡	0.07 ± 0.00	0.03 ± 0.00	0.03 ± 0.00	0.02 ± 0.00	0.03 ± 0.00 ^‡	0.05 ± 0.00	0.02 ± 0.00 ^‡
VII	4	0.02 ± 0.00 ^‡	3.07 ± 0.10 ^‡	0.08 ± 0.01	5.26 ± 0.16	0.13 ± 0.01 ^‡	0.09 ± 0.00 ^‡	0.07 ± 0.00	0.09 ± 0.02	0.05 ± 0.02	0.03 ± 0.00	0.10 ± 0.01	0.03 ± 0.00
	24	0.01 ± 0.00	1.04 ± 0.09 ^‡	0.11 ± 0.03	2.97 ± 0.11	0.09 ± 0.01 ^‡	0.08 ± 0.00 ^‡	0.04 ± 0.00	0.05 ± 0.01	0.03 ± 0.00	0.03 ± 0.00	0.08 ± 0.01	0.02 ± 0.00
	48	0.01 ± 0.00	0.42 ± 0.03 ^‡	0.06 ± 0.00	1.77 ± 0.08	0.06 ± 0.00 ^‡	0.08 ± 0.01	0.04 ± 0.00	0.05 ± 0.01	0.03 ± 0.00 ^‡	0.03 ± 0.00 ^‡	0.08 ± 0.01 ^‡	0.02 ± 0.00 ^‡

↵* Time after injection of DOTA conjugates.
↵^† Tissue radioactivity is expressed as mean ± SEM (n = 4–12).
↵^‡ P < 0.05 vs. DOTA-NAPamide.