TABLE 3

Plasma Clearance Kinetics: ¹¹¹In-J591 vs. ¹⁷⁷Lu-J591

Pharmcokinetic parameter	Biexponential			Monoexponential
Pharmcokinetic parameter		¹¹¹In-J591*	¹⁷⁷Lu-J591*	¹¹¹In-J591	¹⁷⁷Lu-J591
t_1/2 (h)			32.3 ± 8.1	39.1 ± 13.3
α	2.37 ± 1.94	2.04 ± 1.96
β	44.20 ± 13.9	43.60 ± 16.1
AUC	1.19 ± 0.44	1.49 ± 0.63	1.08 ± 0.4	1.42 ± 0.60
C_max (%ID/mL)	0.026 ± 0.001	0.027 ± 0.005	0.023 ± 0.005	0.025 ± 0.005
V_d (mL) at t₀	4,042 ± 863	3,952 ± 1,072	4,467 ± 811	4,156 ± 858
Clearance (mL/h)	94 ± 34	84 ± 46	98 ± 43	88 ± 47

↵* Last time point with ¹¹¹In was 146 ± 13 h and with ¹⁷⁷Lu was 320 ± 15 h.
t₀ = time zero.
The difference between ¹¹¹In and ¹⁷⁷Lu data was statistically insignificant (P > 0.05).