TABLE 2

Tissue Distribution of ⁶⁷Ga- and ¹⁷⁷Lu-BZH3 as Function of Time in AR42J Tumor-Bearing Nude Mice After Injection of 15 pmol of Peptide

Tissue	⁶⁷Ga							¹⁷⁷Lu
Tissue		1 h	2 h	4 h	24 h	1 h	24 h
Blood	0.25 ± 0.02	0.17 ± 0.03	0.12 ± 0.01	0.015 ± 0.006	0.51 ± 0.06	0.025 ± 0.006
Liver	0.47 ± 0.12	0.40 ± 0.05	0.32 ± 0.07	0.22 ± 0.03	0.62 ± 0.06	0.35 ± 0.05
Spleen	3.32 ± 0.90	3.35 ± 1.44	2.26 ± 1.07	0.83 ± 0.24	1.67 ± 0.17	0.31 ± 0.07
Kidneys	6.78 ± 0.40	4.49 ± 0.37	4.12 ± 0.70	1.75 ± 0.40	4.96 ± 0.87	0.72 ± 0.04
Pancreas	42.16 ± 2.30	37.52 ± 6.69	36.54 ± 5.19	20.75 ± 5.24	31.78 ± 3.69	3.71 ± 0.55
Muscle	0.13 ± 0.07	0.11 ± 0.09	0.04 ± 0.02	0.021 ± 0.009	0.13 ± 0.02	0.02 ± 0.005
Bone*	0.39 ± 0.09	0.29 ± 0.03	0.26 ± 0.06	0.20 ± 0.09	0.59 ± 0.08	0.79 ± 0.13
Lungs	0.31 ± 0.04	0.19 ± 0.04	0.13 ± 0.03	0.04 ± 0.01	0.45 ± 0.06	0.05 ± 0.02
Tumor	5.65 ± 0.73	6.47 ± 1.13	5.26 ± 1.30	2.10 ± 0.38	4.52 ± 0.57	1.48 ± 0.23
Small intestine^†	4.74 ± 0.48	3.39 ± 0.38	1.66 ± 0.18	0.85 ± 0.13	4.62 ± 0.95	0.48 ± 0.15
Large intestine^†	4.93 ± 1.13	6.78 ± 0.93	4.90 ± 0.52	1.75 ± 0.86	3.38 ± 1.18	1.22 ± 0.14

↵* One femur was measured.
↵^† Small and large intestines were measured with content.
All data are mean %ID/g ± SD of 5 animals. Body weight of animals, 22.4 ± 2.02 g; tumor weight, 252 ± 130 mg (range, 86–612 mg); pancreas weight, 179 ± 36 mg (n = 30).