TABLE 1

Tissue Distribution of Increasing Doses of ⁶⁷Ga-BZH3 at 1 Hour After Injection in AR42J Tumor-Bearing Nude Mice

Tissue	pmol per animal
Tissue		5	15	45	135
Blood	0.45 ± 0.12	0.57 ± 0.17	0.51 ± 0.14	0.53 ± 0.10
Liver	0.68 ± 0.18	1.12 ± 0.39	0.87 ± 0.23	0.72 ± 0.13
Spleen	2.14 ± 0.49	1.62 ± 0.48	1.82 ± 0.89	1.29 ± 0.54
Kidneys	6.55 ± 1.92	6.32 ± 2.00	4.52 ± 0.59	3.03 ± 0.45
Pancreas	35.98 ± 2.22	40.39 ± 2.81*	46.06 ± 3.51*	39.37 ± 4.57*
Muscle	0.16 ± 0.05	0.13 ± 0.04	0.20 ± 0.07	0.20 ± 0.05
Bone^†	0.37 ± 0.13	0.51 ± 0.22	0.29 ± 0.15	0.48 ± 0.24
Lungs	0.60 ± 0.17	0.63 ± 0.25	0.56 ± 0.15	0.64 ± 0.11
Tumor	7.98 ± 1.57	10.90 ± 1.48*	8.00 ± 1.68*	6.25 ± 0.80
Small intestine^‡	8.70 ± 2.39	7.51 ± 1.45	5.62 ± 0.79	4.00 ± 0.43
Large intestine^‡	3.94 ± 0.24	3.82 ± 0.49	2.96 ± 0.69	1.95 ± 0.49

↵* Significantly different (P ≤ 0.05) from preceding group (Student t test).
↵^† One femur was measured.
↵^‡ Small and large intestines were measured with content.
All data are mean percentage injected dose per gram (%ID/g) ± SD of 5 animals. Body weight of animals, 23.9 ± 1.7 g; tumor weight, 218 ± 104 mg (range, 88–388 mg); pancreas weight, 204 ± 30 mg (n = 20).