TABLE 1

Organ-to-Blood Ratios, Including BBLR and BMBLR, for ²¹¹At- and ^99mTc-Conjugated mAbs MX35 and 88BV59 (n = 90)

	3 h							6 h
		MX35			88BV59			MX35			88BV59			MX35	88BV59
		²¹¹At	^99mTc	²¹¹At	^99mTc	²¹¹At	^99mTc	²¹¹At	^99mTc	²¹¹At	^99mTc	²¹¹At	^99mTc
Blood (cardiac)	1	1	1	1	1	1	1	1	1	1	1	1
Bone (BBLR)	0.18 ± 0.04	0.13 ± 0.05	0.35 ± 0.07	0.12 ± 0.02	0.29 ± 0.05	0.16 ± 0.09	0.45 ± 0.07	0.16 ± 0.04	0.22 ± 0.05	0.11 ± 0.09	0.46 ± 0.09	0.11 ± 0.04
Bone marrow (BMBLR)	0.54 ± 0.12	0.54 ± 0.10	0.58 ± 0.10	0.51 ± 0.10	0.60 ± 0.10	0.61 ± 0.10	0.61 ± 0.12	0.58 ± 0.10	0.59 ± 0.12*	0.58 ± 0.09*	0.58 ± 0.10*	0.56 ± 0.10*
Heart	0.26 ± 0.05	0.35 ± 0.09	0.41 ± 0.07	0.37 ± 0.07	0.36 ± 0.07	0.46 ± 0.09	0.48 ± 0.09	0.50 ± 0.10	0.34 ± 0.07	0.43 ± 0.09	0.45 ± 0.09	0.46 ± 0.09
Kidney	0.27 ± 0.05	0.92 ± 0.12	0.46 ± 0.10	1.59 ± 0.19	0.29 ± 0.05	1.10 ± 0.14	0.62 ± 0.12	1.90 ± 0.24	0.31 ± 0.05	1.06 ± 0.12	0.58 ± 0.10	1.85 ± 0.26
Liver	0.30 ± 0.05	0.31 ± 0.07	0.26 ± 0.05	0.33 ± 0.07	0.34 ± 0.05	0.40 ± 0.09	0.37 ± 0.05	0.54 ± 0.09	0.33 ± 0.07	0.37 ± 0.09	0.37 ± 0.05	0.49 ± 0.09
Lung	0.48 ± 0.07	0.54 ± 0.12	0.66 ± 0.10	0.34 ± 0.09	0.57 ± 0.09	0.62 ± 0.14	0.79 ± 0.16	0.46 ± 0.10	0.49 ± 0.09	0.58 ± 0.12	0.73 ± 0.16	0.43 ± 0.10
Muscle	0.09 ± 0.02	0.11 ± 0.04	0.09 ± 0.02	0.08 ± 0.02	0.11 ± 0.02	0.14 ± 0.04	0.13 ± 0.02	0.13 ± 0.02	0.11 ± 0.02	0.14 ± 0.04	0.12 ± 0.04	0.13 ± 0.04
Small intestine	0.11 ± 0.04	0.29 ± 0.05	0.36 ± 0.07	0.38 ± 0.07	0.17 ± 0.04	0.42 ± 0.09	0.45 ± 0.09	0.49 ± 0.07	0.15 ± 0.04	0.41 ± 0.07	0.42 ± 0.07	0.46 ± 0.09
Spleen	0.33 ± 0.07	0.49 ± 0.09	0.38 ± 0.07	0.48 ± 0.09	0.47 ± 0.09	0.50 ± 0.09	0.49 ± 0.10	0.62 ± 0.12	0.48 ± 0.09	0.51 ± 0.10	0.47 ± 0.07	0.60 ± 0.12
Stomach	0.22 ± 0.04	0.45 ± 0.05	0.66 ± 0.12	0.52 ± 0.05	0.32 ± 0.09	0.58 ± 0.07	0.81 ± 0.14	0.66 ± 0.10	0.34 ± 0.07	0.50 ± 0.05	0.71 ± 0.14	0.63 ± 0.07
Thyroid^†	4.19 ± 0.89	1.76 ± 0.36	6.34 ± 1.15	1.59 ± 0.29	6.02 ± 1.13	2.01 ± 0.46	8.70 ± 1.48	1.82 ± 0.39	6.48 ± 1.24	1.99 ± 0.38	8.93 ± 1.56	1.76 ± 0.32

↵* Extrapolated from ¹²⁵I measurements.
↵^† Activity concentration (ac) in thyroid was calculated considering weight (w) of and activity (a) in throat specimen and a standard weight (sw) of thyroid of 3 mg for nude BALB/c nu/nu mice. Throat was assumed to contain samples of both muscle and thyroid. Calculation was done as follows: Thyroid_ac = (Throat_a − (Throat_w − Thyroid_sw) × Muscle_ac)/Thyroid_sw.
Values are means ± SEM.