TABLE 2

Biodistribution Study by Dissection of 123I-2-Iodo-l-Phenylalanine in R1M-Bearing Athymic Mice (n = 6)

TissueDAR (mean ± SD)
2 min30 min45 min60 min180 min
Blood1.76 ± 0.941.46 ± 0.371.39 ± 0.281.06 ± 0.311.16 ± 0.21
Brain0.34 ± 0.010.49 ± 0.090.55 ± 0.180.63 ± 0.160.47 ± 0.07
Heart1.31 ± 0.150.84 ± 0.230.65 ± 0.090.82 ± 0.040.74 ± 0.18
Lung1.33 ± 0.281.11 ± 0.500.69 ± 0.240.80 ± 0.070.86 ± 0.25
Stomach0.88 ± 0.201.98 ± 1.232.60 ± 1.253.34 ± 0.242.61 ± 1.59
Liver0.88 ± 0.080.52 ± 0.170.42 ± 0.080.53 ± 0.080.56 ± 0.10
Kidneys4.81 ± 2.161.73 ± 0.511.79 ± 0.461.45 ± 0.101.03 ± 0.28
Small intestine0.57 ± 0.050.61 ± 0.080.59 ± 0.200.76 ± 0.120.70 ± 0.23
Large intestine0.41 ± 0.130.29 ± 0.030.18 ± 0.070.32 ± 0.080.44 ± 0.13
Pancreas5.37 ± 1.034.71 ± 1.004.56 ± 1.987.87 ± 2.618.64 ± 1.74
Front leg0.77 ± 0.230.43 ± 0.380.64 ± 0.360.56 ± 0.240.47 ± 0.12
Tumor1.13 ± 0.112.58 ± 0.612.70 ± 0.233.76 ± 0.523.02 ± 0.39
RTB1.61 ± 0.723.58 ± 0.975.02 ± 2.206.71 ± 1.266.35 ± 1.05
  • DAR was calculated at various time points after injection.