TABLE 2

Human Testes (Adult) Uptake and Dosimetry of ²⁰¹Tl-Thallous Chloride: Comparison of Results from Various Investigators

Reference	No. of subjects	Exercise vs. rest	Testicular uptake (% at 24 h)	Testicular biologic t_1/2	Data acquisition method	Estimated radiation dose to testes
Reference	No. of subjects	Exercise vs. rest	Testicular uptake (% at 24 h)	Testicular biologic t_1/2	Data acquisition method			rad/mCi	mGy/MBq
Rao et al. (23)	4	Rest	0.43 ± 0.10	280 h	Anterior imaging, shielded	1.3	0.35
Atkins et al. (14)	3		∼0.15	Long	Imaging, geometric mean	0.59	0.16
Hosain and Hosain (22)			0.8		Extrapolation from animals	1.4	0.4
Gupta et al. (21)	4		∼1.1		Imaging
Krahwinkel et al. (17)	14	Exercise	0.30 ± 0.10	Long	Imaging, geometric mean	0.34 ± 0.21	0.09 ± 0.06
Castronovo (18)	14	Exercise	0.30 ± 0.10	Long	Imaging, geometric mean	0.91	0.25
Nettleton et al. (24)	4		0.19		Orchidectomy	0.41–0.52	0.11–0.14
This study and Stabin et al. (25)	28*	Exercise	0.29 ± 0.09	429 h^†	Anterior imaging, shielded	0.77	0.21
ICRP 80 (20)						1.7	0.45

↵* Fifty-six studies done in 28 patients.
↵^† Obtained from average of biologic half-time (biologic t_1/2) for long biologic component for all patients. Range = 34–5,139 h; SD = 810 h.