Region | VT (mL/g) | Baseline (n = 3) BP (mL/g) | V3″ | VT (mL/g) | After naloxone (n = 3) BP (mL/g) | V3″ |
---|---|---|---|---|---|---|
Cerebellum | 3.7 ± 1.6 | — | — | 3.4 ± 1.2 | — | — |
Brain stem | 5.1 ± 2.9 | 1.4 ± 1.3 | 0.3 ± 0.2 | 3.6 ± 1.8 | 0.3 ± 0.6 | 0.1 ± 0.2 |
Thalamus | 6.9 ± 3.6 | 3.2 ± 2.1 | 0.8 ± 0.3 | 4.1 ± 2.1 | 0.8 ± 0.9 | 0.2 ± 0.2 |
Striatum | 10.5 ± 5.9 | 6.8 ± 4.3 | 1.7 ± 0.5 | 4.7 ± 2.8 | 1.3 ± 1.5 | 0.3 ± 0.3 |
Medial temporal lobe | 7.0 ± 3.8 | 3.3 ± 2.1 | 0.8 ± 0.2 | 4.0 ± 1.8 | 0.6 ± 0.6 | 0.2 ± 0.1 |
Cingulate cortex | 10.9 ± 6.1 | 7.2 ± 4.5 | 1.9 ± 0.4 | 4.9 ± 2.3 | 1.6 ± 1.1 | 0.4 ± 0.1 |
Frontal cortex | 8.5 ± 3.7 | 4.8 ± 2.1 | 1.3 ± 0.2 | 4.3 ± 2.3 | 1.0 ± 1.1 | 0.2 ± 0.2 |
Temporal cortex | 8.1 ± 4.3 | 4.4 ± 2.7 | 1.1 ± 0.2 | 4.4 ± 2.1 | 1.0 ± 0.8 | 0.3 ± 0.1 |
Parietal cortex | 7.5 ± 3.8 | 3.7 ± 2.2 | 1.0 ± 0.2 | 4.1 ± 2.2 | 0.7 ± 1.0 | 0.2 ± 0.2 |
Occipital cortex | 4.9 ± 2.5 | 1.2 ± 0.9 | 0.3 ± 0.1 | 3.7 ± 1.7 | 0.3 ± 0.5 | 0.1 ± 0.1 |
Values are mean ± SD. Naloxone has no significant effect on VT in CER (P = 0.77; paired t test). Effect of naloxone on regional V3″ is highly significant (repeated-measures ANOVA, effect of condition, P ≤ 0.0001).