Comparison of Compartment Models for 11C-GR103545 Kinetic Analysis
| Region | Model | VT (mL/g) | SE (%CV) | Goodness of fit AIC | 2TCM superior to 1TCM* |
|---|---|---|---|---|---|
| Cerebellum | 1TCM | 3.3 ± 0.6 | 3.6 ± 2.1 | −78 ± 22 | |
| 2TCM | 3.6 ± 0.6 | 2.6 ± 2.4 | −139 ± 25 | 4 | |
| Brain stem | 1TCM | 4.5 ± 2.6 | 3.2 ± 1.8 | −86 ± 23 | |
| 2TCM | 5.0 ± 2.4 | 3.7 ± 2.9 | −129 ± 16 | 4 | |
| Thalamus | 1TCM | 6.8 ± 3.0 | 2.9 ± 1.1 | −83 ± 23 | |
| 2TCM | 7.2 ± 3.0 | 2.5 ± 1.4 | −113 ± 23 | 3 | |
| Striatum | 1TCM | 10.2 ± 4.9 | 2.3 ± 1.0 | −102 ± 32 | |
| 2TCM | 9.8 ± 4.9 | 2.7 ± 1.3 | −117 ± 34 | 3 | |
| Medial temporal lobe | 1TCM | 6.2 ± 3.1 | 3.1 ± 1.4 | −87 ± 23 | |
| 2TCM | 6.7 ± 3.1 | 3.3 ± 1.8 | −113 ± 28 | 3 | |
| Cingulate cortex | 1TCM | 10.0 ± 5.3 | 2.9 ± 1.1 | −88 ± 25 | |
| 2TCM | 10.5 ± 5.0 | 2.8 ± 1.6 | −114 ± 40 | 3 | |
| Frontal cortex | 1TCM | 7.2 ± 3.4 | 2.8 ± 1.8 | −98 ± 30 | |
| 2TCM | 7.9 ± 3.3 | 2.6 ± 2.2 | −143 ± 25 | 4 | |
| Temporal cortex | 1TCM | 7.3 ± 3.7 | 2.5 ± 1.3 | −90 ± 27 | |
| 2TCM | 7.7 ± 3.6 | 2.1 ± 1.5 | −135 ± 22 | 4 | |
| Parietal cortex | 1TCM | 6.8 ± 3.2 | 1.6 ± 0.5 | −101 ± 31 | |
| 2TCM | 7.2 ± 3.2 | 1.0 ± 0.3 | −149 ± 25 | 4 | |
| Occipital cortex | 1TCM | 4.4 ± 2.2 | 2.9 ± 1.3 | −79 ± 25 | |
| 2TCM | 4.8 ± 2.1 | 1.7 ± 1.1 | −139 ± 25 | 4 |
↵* Number of studies (of 4) in which F test indicates significantly better fit (P ≤ 0.05) for 2TCM than for 1TCM.
1TCM = 1-tissue-compartment model; 2TCM = 2-tissue-compartment model; AIC = Akaike information criterion.
Values are mean ± SD of 4 experiments. VT is significantly larger with 2TCM (repeated-measures ANOVA, effect of model, P ≤ 0.0001). Fit was significantly better (AIC more negative) with 2TCM (repeated-measures ANOVA, effect of model, P ≤ 0.0001).