TABLE 1

Biodistribution of ¹²⁵I-c(RGD(I)yV) in Control and Hindlimb Ischemic Mice

Tissue	Control (n = 8)	Hindlimb ischemia model
Tissue	Control (n = 8)			3 d (n = 6)	8 d (n = 6)	14 d (n = 6)
Blood	0.41 ± 0.20	0.39 ± 0.09	0.28 ± 0.07	0.31 ± 0.10
Heart	0.18 ± 0.09	0.20 ± 0.04	0.12 ± 0.03	0.13 ± 0.04
Lung	0.43 ± 0.19	0.38 ± 0.15	0.29 ± 0.08	0.30 ± 0.09
Liver	0.68 ± 0.37	0.99 ± 0.24	1.05 ± 0.33	0.60 ± 0.23
Spleen	0.29 ± 0.12	0.32 ± 0.07	0.23 ± 0.04	0.23 ± 0.12
Pancreas	0.16 ± 0.09	0.24 ± 0.06	0.14 ± 0.06	0.15 ± 0.04
Kidneys	0.85 ± 0.27	1.02 ± 0.31	0.84 ± 0.19	0.63 ± 0.27
Hindlimb muscle*	0.16 ± 0.05	0.85 ± 0.76^†	0.43 ± 0.23^†	0.43 ± 0.28^†

↵* Ischemic limb for ischemic models and average of both limbs for controls.
↵^† P < 0.05 compared with control values.
Values are expressed as mean ± SD of %ID/g of tissue at 4 h after injection.