Biodistribution of 67Ga-Complex 1b in FVB WT and mdr1a/1b(−/−) Mice (AUC5–120; %ID/g × min)
| Tissue | WT | Mdr1a/1b(−/−) |
|---|---|---|
| Blood | 24.5 ± 9.9 | 29.4 ± 8.7 |
| Heart | 817.5 ± 68.9 | 950.1 ± 123.6 |
| Liver | 1,204.6 ± 147.3 | 2,465.4 ± 440.4 |
| Kidney | 3,921.3 ± 410.4 | 4,072.6 ± 271.8 |
| Brain | 3.7 ± 0.3 | 62.5 ± 16.1 |
| Lung | 131.8 ± 15.8 | 357.5 ± 67.8 |
| Spleen | 92.2 ± 10.5 | 423.1 ± 71.7 |
| Muscle | 96.2 ± 9.0 | 109.0 ± 13.0 |
| Fat | 9.8 ± 2.0 | 22.0 ± 3.6 |
| Bone | 68.4 ± 6.5 | 112.5 ± 17.7 |
| Small intestine | 2,408.4 ± 203.8 | 1,404.9 ± 96.4 |
| Large intestine | 1,647.4 ± 295.2 | 516.4 ± 56.4 |
| Skin | 36.8 ± 4.0 | 65.1 ± 14.7 |
Biodistribution of 67Ga-complex 1b in FVB mice (AUC5–120). Biodistribution data for each tissue are presented as AUC5–120 values of 67Ga-complex 1b expressed as kBq (injected kBq)−1 (g tissue)−1 × 100 × min ± range or ± SEM of 2 or 3 determinations, respectively.