Time point (min) | Organ | %ID/g (mean ± range) | Tissue-to-blood ratio |
---|---|---|---|
5 | Blood | 0.65 ± 0.00 | |
Lung | 4.30 ± 0.93 | 6.6 | |
Liver | 27.24 ± 0.30 | 41.9 | |
Spleen | 4.23 ± 0.26 | 6.5 | |
Kidneys | 37.02 ± 3.35 | 57.0 | |
Muscle | 0.87 ± 0.05 | 1.3 | |
Fat | 0.11 ± 0.02 | 0.2 | |
Heart | 8.62 ± 1.27 | 13.3 | |
Brain | 0.61 ± 0.09 | 0.9 | |
Bone | 1.17 ± 0.15 | 1.8 | |
Small intestine | 7.90 ± 1.25 | 12.2 | |
Large intestine | 2.48 ± 0.39 | 3.8 | |
Skin | 0.57 ± 0.16 | 0.9 | |
15 | Blood | 0.30 ± 0.13 | |
Lung | 4.75 ± 1.11 | 15.8 | |
Liver | 21.69 ± 3.47 | 72.3 | |
Spleen | 4.93 ± 1.27 | 16.4 | |
Kidneys | 37.87 ± 4.27 | 126 | |
Muscle | 1.15 ± 0.23 | 3.8 | |
Fat | 0.24 ± 0.05 | 0.8 | |
Heart | 9.19 ± 2.08 | 30.6 | |
Brain | 0.64 ± 0.26 | 2.1 | |
Bone | 1.34 ± 0.30 | 4.5 | |
Small intestine | 8.73 ± 1.46 | 29.1 | |
Large intestine | 2.61 ± 0.72 | 8.7 | |
Skin | 0.67 ± 0.25 | 2.2 | |
60 | Blood | 0.26 ± 0.06 | |
Lung | 2.96 ± 0.18 | 11.4 | |
Liver | 23.17 ± 5.05 | 89.1 | |
Spleen | 4.01 ± 0.06 | 15.4 | |
Kidneys | 38.51 ± 1.11 | 148 | |
Muscle | 0.91 ± 0.02 | 3.5 | |
Fat | 0.23 ± 0.03 | 0.9 | |
Heart | 8.68 ± 0.28 | 33.4 | |
Brain | 0.54 ± 0.09 | 2.1 | |
Bone | 0.97 ± 0.05 | 3.7 | |
Small intestine | 12.46 ± 0.42 | 47.9 | |
Large intestine | 2.95 ± 0.14 | 11.3 | |
Skin | 0.60 ± 0.01 | 2.3 | |
120 | Blood | 0.14 ± 0.04 | |
Lung | 1.67 ± 0.11 | 11.9 | |
Liver | 17.22 ± 0.70 | 123 | |
Spleen | 1.86 ± 0.05 | 13.3 | |
Kidneys | 27.47 ± 0.83 | 196 | |
Muscle | 0.83 ± 0.02 | 5.9 | |
Fat | 0.09 ± 0.01 | 0.6 | |
Heart | 6.62 ± 0.21 | 47.3 | |
Brain | 0.44 ± 0.01 | 3.1 | |
Bone | 0.63 ± 0.01 | 4.5 | |
Small intestine | 15.71 ± 0.43 | 112 | |
Large intestine | 9.24 ± 0.62 | 66.0 | |
Skin | 0.40 ± 0.03 | 2.9 |
Pharmacokinetics of 67Ga-complex 1b in FVB mdr1a/1b(−/−) mice. Mice were injected intravenously with 74 kBq (2 μCi) of 67Ga-complex 1b and sacrificed at 5, 15, 60, or 120 min after injection; blood and tissues were harvested and counted. Data are expressed as %ID/g tissue at each time point. Values represent mean ± range (n = 2). Also shown are tissue-to-blood ratios at each time point.