Time point (min) | Organ | %ID/g (mean ± SEM) | Tissue-to-blood ratio |
---|---|---|---|
5 | Blood | 1.29 ± 0.29 | |
Lung | 2.11 ± 0.25 | 1.6 | |
Liver | 25.58 ± 0.36 | 19.8 | |
Spleen | 2.02 ± 0.12 | 1.6 | |
Kidneys | 40.27 ± 3.91 | 31.2 | |
Muscle | 0.82 ± 0.07 | 0.6 | |
Fat | 0.17 ± 0.05 | 0.1 | |
Heart | 8.39 ± 1.22 | 6.5 | |
Brain | 0.06 ± 0.01 | 0.0 | |
Bone | 0.89 ± 0.11 | 0.7 | |
Small intestine | 10.71 ± 1.57 | 8.3 | |
Large intestine | 3.11 ± 0.57 | 2.4 | |
Skin | 0.45 ± 0.07 | 0.3 | |
15 | Blood | 0.43 ± 0.12 | |
Lung | 1.72 ± 0.19 | 4.0 | |
Liver | 21.12 ± 2.49 | 49.1 | |
Spleen | 1.40 ± 0.13 | 3.3 | |
Kidneys | 36.15 ± 0.83 | 84.1 | |
Muscle | 0.79 ± 0.14 | 1.8 | |
Fat | 0.09 ± 0.01 | 0.2 | |
Heart | 7.01 ± 0.54 | 16.3 | |
Brain | 0.04 ± 0.00 | 0.1 | |
Bone | 0.82 ± 0.06 | 1.9 | |
Small intestine | 15.57 ± 0.51 | 36.2 | |
Large intestine | 2.61 ± 0.18 | 6.1 | |
Skin | 0.35 ± 0.04 | 0.8 | |
60 | Blood | 0.10 ± 0.00 | |
Lung | 0.94 ± 0.12 | 9.4 | |
Liver | 7.58 ± 0.35 | 75.8 | |
Spleen | 0.60 ± 0.09 | 6.0 | |
Kidneys | 34.40 ± 4.83 | 344 | |
Muscle | 0.83 ± 0.03 | 8.3 | |
Fat | 0.07 ± 0.02 | 0.7 | |
Heart | 6.92 ± 0.61 | 69.2 | |
Brain | 0.03 ± 0.00 | 0.3 | |
Bone | 0.56 ± 0.06 | 5.6 | |
Small intestine | 29.41 ± 2.21 | 294 | |
Large intestine | 5.52 ± 1.60 | 55.2 | |
Skin | 0.30 ± 0.04 | 3.0 | |
120 | Blood | 0.03 ± 0.00 | |
Lung | 0.81 ± 0.04 | 27.0 | |
Liver | 3.26 ± 0.59 | 108 | |
Spleen | 0.40 ± 0.01 | 13.3 | |
Kidneys | 30.66 ± 2.19 | 1,022 | |
Muscle | 0.89 ± 0.06 | 29.7 | |
Fat | 0.08 ± 0.01 | 2.7 | |
Heart | 7.31 ± 0.47 | 243 | |
Brain | 0.03 ± 0.00 | 1.0 | |
Bone | 0.41 ± 0.04 | 13.7 | |
Small intestine | 12.76 ± 1.67 | 425 | |
Large intestine | 42.35 ± 4.55 | 1,411 | |
Skin | 0.29 ± 0.01 | 9.7 |
Pharmacokinetics of 67Ga-complex 1b in FVB WT mice. Mice were injected intravenously with 74 kBq (2 μCi) of 67Ga-complex 1b and sacrificed at 5, 15, 60, or 120 min after injection; blood and tissues were harvested and counted. Data are expressed as %ID/g tissue at each time point. Values represent mean ± SEM (n = 3). Also shown are tissue-to-blood ratios at each time point.