Clinical Characteristics of Patients
| Patient no. | Age (y) | Sex | Disease duration (y) | Onset symptoms/main symptoms at initial examination | MMSE score | Group* |
|---|---|---|---|---|---|---|
| 1 | 79 | M | 4 | Naming difficulty/hoarding, wandering, excessive eating, indifferent to personal hygiene. | 23 | L |
| 2 | 61 | F | 2 | Forgetfulness/shamelessness, urinary incontinence, reduced spontaneous speech, unable to stay still in one place, easily distracted, stupefied. | 16 | R |
| 3 | 59 | M | 2.5 | Naming difficulty/stubbornness, hoarding, decreased spontaneous speech, abusive language, easily irritated, overeats, tendency to go outside, organizing objects in a straight line. | 12 | L |
| 4 | 70 | F | 3 | Cause an estrangement among family members/overeats, uses abusive language, lies, excessive laughing, wasting money, becomes lazy, wanders about. | 18 | R |
| 5 | 50 | F | 1 | Buy an unknown kid a soft-drink everyday/increased stubbornness, reduced spontaneous speech, unable to finish a task, became lazy, dull-witted, not exchange greetings, overeats. | 23 | R |
| 6 | 68 | F | 3 | Memory impairment, decreased verbal output/walks up and down restlessly all day long, frequently laughs, touches objects around her, does not speak unless spoken to. | 1 | R |
| 7 | 40 | F | 2 | Doubt of husband/unable to control emotions, abusive language, became shameless, naming difficulty, urinary incontinence, tendency to urinate anywhere, undresses herself on the streets. | 3 | L |
| 8 | 58 | F | 3 | Inappropriate investment/caresses other people’s faces, repeats the same questions, excessive laughing, dull-witted, stubborn, steals object, wastes money. | 24 | L |
| 9 | 52 | F | 3 | Indifferent to housework/wanders about in the house, goes to the bathroom too often, compulsively reads words or sentences on TV, frequent laughing, reduced spontaneous speech. | 2 | L |
| 10 | 58 | M | 2.5 | Smokes a cigarette butt/urinates anywhere, shameless and dull-witted, quarrels with customers (runs a shop), became lazy, stubborn, excessively frugal, takes remaining food from wedding ceremonies, overeating, wanders about the house. | 24 | B |
| 11 | 65 | F | 2 | Increased stubbornness/lacking in judgment, stubborn, became aggressive, became verbose, obsessive about money, abusive language, thoughtless remarks, laughs too often. | 0 | L |
| 12 | 66 | F | 2 | Steals/stinginess, asks her relatives for money, overeats, excessive laughing, hides her daughter’s underwear in her drawers, inserts his candy in a passerby’s mouth, hugs a stranger. | 23 | L |
| 13 | 58 | F | 2 | Character change, inappropriate judgment/dull-witted, likes free gifts, became lazy, overeats, wanders around downtown all day. | 28 | R |
| 14 | 51 | M | 3 | Decreased verbal output/fingers objects, goes in and out of the bathroom frequently, tendency to go outside, decrease of spontaneous speech, overeats. | 5 | L |
| 15 | 62 | F | 4 | Impairment in verbal expression/mistrust of others, object-naming difficulty, comprehension deficit, indifferent to others, loss of interest, obsessed with one task. | NA | L |
| 16 | 51 | M | 4 | Did not attend social meeting/overeats, frequently irritated, indifferent, inappropriate laughing, wanders about in the house, roams outside, unable to stay in one place, easily distracted. | 27 | L |
| 17 | 53 | M | 3 | Indifferent to family members/does not talk to others, tells jokes to strange women, collision accident while driving, inappropriate laughing, wandering outside all day long. | 22 | R |
| 18 | 41 | M | 1 | Nervous to nephews/reduced speech, avoids stepping on line while walking, became generous, likes sweets, became stubborn, frequent visits to the bathroom. | 12 | L |
| 19 | 66 | F | 1 | Talks and laughs loudly in public places/overeats, violent, impatient, wandering outside. | 20 | L |
| 20 | 73 | F | 4 | Opens and closes doors frequently, fumbles both hands/became generous, smiles frequently, progressive reduction of speech, urinary incontinence. | 4 | L |
| 21 | 41 | F | 5 | Indifferent to housework/apathy, indifference, careless housekeeping, urinary incontinence. | 23 | B |
| 22 | 41 | M | 1 | Decreased verbal output and inappropriate judgment/repetitive behaviors, abusive language, depressive mood. | 18 | B |
| 23 | 55 | F | 1.5 | Naming difficulty/naming deficit, laughs away mistakes, comprehension deficit, increased appetite. | 5 | L |
| 24 | 63 | F | 3 | Become fastidious/laughs often, stubborn, wandering, decreased spontaneous speech, reduced ability to concentrate. | NA | L |
| 25 | 58 | M | 4 | Memory impairment/short utterances, easily frustrated, dull-witted, shameless, steals objects, decreased concentration ability, became stubborn, overeats, wanders all day long. | 14 | R |
| 26 | 76 | F | 1.5 | Naming difficulty/loss of interest, became lazy, reduced spontaneous speech. | 18 | L |
| 27 | 60 | F | 1 | Verbal expression impairment/reduced spontaneous speech, loss of interest, depressive mood. | 26 | L |
| 28 | 57 | M | 2 | Repeat same word/comprehension difficulty, excessive purchase of cheap objects, excessive purchase of lottery tickets, stubborn, indifferent, apathy. | 16 | L |
| 29 | 74 | F | 1 | Forgetfulness/fingering objects, reads everything she sees, decreased spontaneous speech, urinary incontinence. | 25 | R |
↵* According to AIROI, individual patients were classified into either left-dominant (hypometabolism more severe in the left hemisphere) (L), right-dominant (R), or bilateral group (B).
MMSE = Mini-Mental State Examination; NA = not available.