TABLE 3

Brain Distribution of Compound 1

Tissue	%ID/g ± SD (n = 3)
		5 min	15 min	30 min	60 min	LSA
		5 min	15 min	30 min	60 min					30 min	60 min
CB	1.66 ± 0.50	1.38 ± 0.32	1.16 ± 0.19	0.84 ± 0.05	1.00 ± 0.06	0.65 ± 0.07
HIPP	1.24 ± 0.33	1.12 ± 0.15	0.91 ± 0.05	0.81 ± 0.10	1.27 ± 0.09	0.98 ± 0.16
STR	1.47 ± 0.38	1.20 ± 0.15	0.93 ± 0.10	0.69 ± 0.06	1.20 ± 0.05	0.75 ± 0.22
CTX	1.46 ± 0.48	1.28 ± 0.21	0.89 ± 0.11	0.69 ± 0.10	1.16 ± 0.13	0.86 ± 0.15
THAL	1.61 ± 0.61	1.35 ± 0.28	1.11 ± 0.06	0.77 ± 0.10	1.23 ± 0.12	0.81 ± 0.06
S. COLL	1.49 ± 0.50	1.42 ± 0.26	1.09 ± 0.14	0.88 ± 0.16	1.04 ± 0.15	0.88 ± 0.16

CB = cerebellum; HIPP = hippocampus; STR = striatum; CTX = cortex; THAL = thalamus; S. COLL = superior colliculus.