TABLE 1

Binding Affinities and Selectivities

LabelKi, nmol/Lα4β2/α75-HT3/α7
111C0.54 (1)>22,000 (1)18 (1)
211C5.8 (3)14,000 (1)1100 (1)
3 (precursor)*125I18 (3)36000 (1)280 (1)
4125I0.26 (2)NP2.2 (1)†

  • ↵* Values refer to precursor to radiolabeled compound.

  • ↵† Performed on human 5-HT3R; all other values are for rat.

  • NP = not performed.

    Number of determinations in parentheses.