TABLE 1

Average FLT Parameter Estimates and Range for Tumor, Marrow, and Muscle

Time (min)	Model	K₁ (mL/min/g)	V_d (mL/g)	k₃ (1/min)	k₄ (1/min)	K_FLT (mL/min/100 g)	n
Tumor
120	4P	0.15 (0.03–0.37)	0.95 (0.30–2.43)	0.22 (0.05–0.54)	0.021 (0.011–0.050)	0.064 (0.014–0.099)	10
90	4P	0.15 (0.03–0.32)	0.98 (0.27–3.07)	0.24 (0.06–0.63)	0.019 (0.001–0.052)	0.061 (0.015–0.100)	18
60	4P	0.16 (0.03–0.37)	1.12 (0.22–4.35)	0.26 (0.01–0.78)	0.009 (0.001–0.049)	0.058 (0.005–0.101)	18
60	3P	0.16 (0.03–0.64)	2.01 (0.17–4.96)	0.07 (0.02–0.40)	—	0.047 (0.009–0.071)	18
Graphical		—	—	—	—	0.046 (0.010–0.076)	18
Marrow
120	4P	0.11 (0.09–0.15)	3.42 (0.37–8.52)	0.21 (0.04–0.39)	0.006 (0.001–0.014)	0.078 (0.058–0.109)	9
90	4P	0.11 (0.06–0.19)	2.78 (0.29–7.74)	0.39 (0.04–0.97)	0.008 (0.001–0.023)	0.076 (0.051–0.133)	17
60	4P	0.10 (0.05–0.18)	2.26 (0.26–8.87)	0.25 (0.03–0.80)	0.009 (0.001–0.031)	0.070 (0.041–0.096)	17
60	3P	0.10 (0.05–0.18)	3.85 (0.44–9.17)	0.25 (0.03–0.80)	—	0.066 (0.045–0.089)	17
Graphical		—	—	—	—	0.067 (0.047–0.095)	17
Muscle
120	4P	0.03 (0.01–0.07)	0.67 (0.23–1.30)	0.03 (0.00–0.10)	0.019 (0.001–0.053)	0.009 (0.003–0.015)	9
90	4P	0.03 (0.01–0.18)	0.65 (0.02–1.35)	0.06 (0.00–0.68)	0.033 (0.002–0.095)	0.007 (0.003–0.014)	17
60	4P	0.02 (0.01–0.06)	0.63 (0.14–1.50)	0.08 (0.00–0.34)	0.094 (0.002–0.397)	0.005 (0.001–0.017)	17
60	3P	0.02 (0.01–0.06)	0.76 (0.32–1.43)	0.01 (0.00–0.02)	—	0.003 (0.001–0.008)	17
Graphical		—	—	—	—	0.004 (0.001–0.007)	17

4P = 2-compartment, 4-parameter (K₁, V_d, k₃, k₄); 3P = 2-compartment, 3-parameter (K₁, V_d, k₃) with k₄ fixed to zero; Graphical = estimation of K_FLT from 15- to 50-min interval.