TABLE 2

Effects of Pharmacologic Interventions on Kinetics of Myocardial 124I-FIAU in HSV1-tk and LacZ Hearts

ParameterBaselineF-Ara-AMPThymidineP (ANOVA)
HSV1-tk
    Ki (mL/g/min)0.19 ± 0.020.11 ± 0.01*0.04 ± 0.01†<0.0001
    Ko (mL/g/min)0.04 ± 0.0040.05 ± 0.0020.05 ± 0.010.0426
    Vd (mL/g)4.90 ± 0.982.09 ± 0.19*0.83 ± 0.22†0.0007
LacZ
    Ki (mL/g/min)0.08 ± 0.010.05 ± 0.004‡0.005 ± 0.003†<0.0001
    Ko (mL/g/min)0.07 ± 0.0010.06 ± 0.0030.08 ± 0.0040.0649
    Vd (mL/g)1.29 ± 0.210.85 ± 0.080.06 ± 0.04†<0.0001

  • ↵* P < 0.01 vs. HSV1-tk.

  • ↵† P < 0.001 vs. baseline.

  • ↵‡ P < 0.05 (Tukey–Kramer post hoc test).