Antigens on Pediatric Brain Tumors Targeted by Radioimmunotherapy
| Antigen | Antibody | Isotope(s) | Disease(s) | Application(s) |
|---|---|---|---|---|
| EGF-R | 425 (44) | 125I | High grade glioma, astrocytoma | Intravenous and intraarterial RIT |
| GD2 | 3F8 (30,39) | 131I | Glioma, ependymoma, astrocytoma, primitive neuroectodermal tumor, schwannoma, meningioma | RID, RIT |
| 14G2a (23) | 131I | RID | ||
| Ch14.18 (24) | 99mTc | RID | ||
| Gp58 | 8H9 (27,28) | 131I | Glioma, ependymoma, astrocytoma, primitive neuroectodermal tumor, schwannoma, meningioma, neurofibroma, pinealoblastoma | RID, RIT |
| L1 | UJ181.4 (46,47) | 131I | Primitive neuroectodermal tumor, pinealoblastoma | Intravenous RIT |
| M340 (46,47) | 131I | Intravenous RIT | ||
| NCAM | ERIC-1 (45) | 90Y | Malignant glioma | Intracavitary RIT |
| UJ13A (47) | 131I | Primitive neuroectodermal tumor | Intravenous RIT | |
| Tenascin | 81C6 (4,42,43) | 131I, 211At | High-grade glioma | Intracavitary and intrathecal RIT |
| BC4 (1,2) | 131I, 90Y | Intralesional RIT | ||
| Biotinylated BC4 (3) | 90Y | Intravenous RIT |
RID = radioimmunodetection.