Antigens on Pediatric Hematologic Malignancies Targeted by Radioimmunotherapy
| Antigen | Antibody | Isotope(s) | Disease(s) |
|---|---|---|---|
| CD10* | WCMH15.14 (16,17) | 131I | Acute lymphoblastic lymphoma |
| CD19* | HD37 (16,17) | 131I | Acute lymphoblastic lymphoma |
| CD20 | Tositumomab (5) | 131I | Non-Hodgkin’s lymphoma, Hodgkin’s disease |
| Ibritumomab tiuxetan (6) | 90Y | ||
| B9E9FP fusion protein (7) | 90Y | ||
| CD21 | OKB7 (8) | 131I | Non-Hodgkin’s lymphoma |
| CD22 | Epratuzumab (9) | 90Y, 131I, 186Re | Non-Hodgkin’s lymphoma |
| CD33 | HuM195 (11) | 131I, 90Y, 213Bi | Acute myeloid leukemia |
| P67 (10) | 131I | Acute myeloid leukemia | |
| CD45 | BC8 (12) | 131I | Acute myeloid leukemia, acute lymphoblastic lymphoma, myelodysplastic syndrome |
| CD5 | T101 (13) | 90Y | T-cell acute lymphoblastic leukemia |
| CD66 | BW250/183 (14) | 188Re | Acute myeloid leukemia, acute lymphoblastic lymphoma |
| HLA-DR | Lym-1 (15) | 67Cu, 131I, 90Y | Non-Hodgkin’s lymphoma |
↵* Antigens targeted on pediatric leukemia previously targeted by RIT.