Patient Characteristics
| Patient | Sex | Age (y) | Tumor classification | Pre-177Lu-DOTATATE therapy | 177Lu-DOTATATE therapy | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Prior therapy | Tg (μg/mL)* | TSH (mU/L)† | 131I/123I scan‡ | 111In-octreotide§ | PD‖ | Cumulative dose (GBq) | No. of treatments | ||||||||||
| 1 | M | 52 | PTC | TT, ND, RIT (16.7 GBq)¶, R | 49.1 | 0.168 | − | 2 | Yes | 25.7 | 8 | ||||||
| 2 | F | 73 | FTC | TT, RIT (10.6 GBq), R, C | 5665 | <0.01 | − | 2 | Yes | 22.4 | 3 | ||||||
| 3 | F | 52 | HCTC | TT, ND, RIT (1.9 GBq) | 1110 | 0.02 | − | 3 | Yes | 27.4 | 8 | ||||||
| 4 | F | 74 | HCTC | TT, RIT (12.9 GBq) | 126 | NA | + | 2 | No | 30.1 | 4 | ||||||
| 5 | F | 52 | HCTC | TT, RIT (13.0 GBq), R | 237 | 0.24 | ± | 1 | No | 22.7 | 3 | ||||||
↵* Serum Tg level during levothyroxine treatment before 177Lu-DOTATATE therapy.
↵† TSH during levothyroxine treatment.
↵‡ Outcomes of radioiodine scan. + = positive; − = negative; ± = mixed.
↵§ Tumor uptake score on 111In-octreotide scintigraphy. 1 = uptake in lesion < uptake in liver; 2 = uptake in lesion = uptake in liver; 3 = uptake in lesion > uptake in liver (as described in [19]).
↵‖ Documented PD within 1 y before therapy.
↵¶ RIT, 131I therapy (cumulative dose).
TT = total thyroidectomy; ND = neck dissection; R = external radiation; C = chemotherapy; NA = not available.