Dosimetric Calculations and Estimation of Worst-Case Effective Doses for 123I-2-Iodo-d-Phenylalanine, 123I-2-Iodo-l-Phenylalanine, and 123I-2-Iodo-l-Tyrosine (n = 3)*
| Organ | 2-Iodo-d-phenylalanine | 2-Iodo-l-phenylalanine | 2-Iodo-l-tyrosine | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Dose %IA | Dose %IA/g | Dose %IA | Dose %IA/g | Dose %IA | Dose %IA/g | ||||
| Adrenal glands | 1.56E−02 | 9.24E−03 | 1.39E−02 | 1.04E−02 | 2.38E−02 | 1.26E−02 | |||
| Brain | 4.95E−03 | 5.18E−03 | 4.37E−03 | 6.37E−03 | 1.14E−02 | 1.30E−02 | |||
| Breasts | 6.23E−03 | 5.59E−03 | 5.95E−03 | 6.46E−03 | 6.07E−03 | 6.26E−03 | |||
| Gallbladder wall | 1.78E−02 | 9.61E−03 | 1.52E−02 | 1.09E−02 | 2.66E−02 | 1.33E−02 | |||
| LLI wall | 2.46E−02 | 8.98E−03 | 2.85E−02 | 2.02E−02 | 4.92E−02 | 1.94E−02 | |||
| Small intestine | 3.41E−02 | 1.15E−02 | 2.59E−02 | 1.42E−02 | 4.02E−02 | 1.48E−02 | |||
| Stomach | 1.28E−01 | 1.92E−02 | 5.49E−02 | 1.30E−02 | 5.83E−02 | 1.36E−02 | |||
| ULI wall | 2.88E−02 | 9.20E−03 | 2.21E−02 | 1.16E−02 | 4.55E−02 | 1.28E−02 | |||
| Heart wall | 1.32E−02 | 1.01E−02 | 1.05E−02 | 9.36E−03 | 1.81E−02 | 1.49E−02 | |||
| Kidneys | 2.07E−02 | 8.02E−03 | 9.07E−03 | 6.00E−03 | 5.20E−02 | 1.84E−02 | |||
| Liver | 1.69E−02 | 8.29E−03 | 1.24E−02 | 6.92E−03 | 3.64E−02 | 1.62E−02 | |||
| Lungs | 8.89E−03 | 9.44E−03 | 6.99E−03 | 8.08E−03 | 1.18E−02 | 1.49E−02 | |||
| Muscle | 8.94E−03 | 7.00E−03 | 1.07E−02 | 1.06E−02 | 1.14E−02 | 9.92E−03 | |||
| Ovaries | 1.51E−02 | 9.34E−03 | 2.19E−02 | 2.00E−02 | 2.50E−02 | 1.80E−02 | |||
| Pancreas | 1.98E−01 | 4.27E−02 | 2.14E−01 | 4.91E−02 | 5.41E−01 | 1.24E−01 | |||
| Red marrow | 8.77E−03 | 6.87E−03 | 9.35E−03 | 9.28E−03 | 1.07E−02 | 8.91E−03 | |||
| Bone surfaces | 1.47E−02 | 1.28E−02 | 1.56E−02 | 1.65E−02 | 1.65E−02 | 1.57E−02 | |||
| Skin | 5.49E−03 | 4.92E−03 | 6.03E−03 | 6.53E−03 | 5.84E−03 | 5.95E−03 | |||
| Spleen | 2.32E−02 | 8.90E−03 | 2.37E−02 | 1.03E−02 | 3.93E−02 | 1.40E−02 | |||
| Testes | 6.85E−03 | 6.63E−03 | 1.36E−02 | 1.46E−02 | 1.19E−02 | 1.26E−02 | |||
| Thymus | 7.93E−03 | 7.50E−03 | 7.77E−03 | 8.68E−03 | 7.72E−03 | 8.36E−03 | |||
| Thyroid | 7.44E−03 | 7.42E−03 | 7.60E−03 | 8.85E−03 | 6.79E−03 | 8.00E−03 | |||
| Urine bladder wall | 9.93E−03 | 9.29E−03 | 3.02E−01 | 3.03E−01 | 2.61E−01 | 2.60E−01 | |||
| Uterus | 1.33E−02 | 9.40E−03 | 3.64E−02 | 3.55E−02 | 3.49E−02 | 3.12E−02 | |||
| Total body | 1.03E−02 | 7.50E−03 | 1.14E−02 | 1.09E−02 | 1.38E−02 | 1.08E−02 | |||
| Worst-case dose (mSv/MBq) | 3.30E−02 | 3.75E−02 | 5.42E−02 | ||||||
↵* Doses are expressed as mGy/MBq, unless otherwise indicated. Calculations for dose %IA and dose %AI/g were performed assuming that values for either %IA/weighttissue or %IAtissue were equal in mice and humans.
LLI = lower large intestine; ULI = upper large intestine.