TABLE 1

Biodistribution of ²¹¹At-Labeled MX35 F(Ab′)₂ in Nude Mice

Sample	Mean ± SEM* %IA/g at following time after injection (h):
Sample		0.5	1.0	2.0	3.4	5.2	7.0	9.4	12.9	17.0	21.2	27.4
Blood	37.5 ± 0.7	30.5 ± 0.3	21.2 ± 2.0	19.1 ± 0.7	14.3 ± 0.4	11.1 ± 0.1	6.6 ± 0.3	5.0 ± 0.2	4.0 ± 0.1	2.8 ± 0.1	1.6 ± 0.0
Salivary glands	3.0 ± 0.3	3.9 ± 0.3	5.3 ± 0.5	7.9 ± 0.2	8.1 ± 0.5	8.2 ± 1.7	6.0 ± 0.7	10.3 ± 3.1	10.7 ± 0.8	7.0 ± 1.1	3.6 ± 0.5
Throat	5.6 ± 0.2	11.6 ± 1.6	16.2 ± 3.2	36.9 ± 4.6	23.7 ± 1.5	27.6 ± 5.6	24.0 ± 5.4	39.2 ± 3.7	40.5 ± 8.9	33.9 ± 3.3	32.0 ± 5.1
Lungs	13.4 ± 1.0	11.9 ± 0.3	11.5 ± 1.6	12.3 ± 0.8	10.4 ± 0.5	8.8 ± 0.3	6.1 ± 0.3	6.2 ± 0.2	6.6 ± 0.7	5.3 ± 0.1	3.8 ± 0.2
Heart	10.7 ± 0.7	10.0 ± 0.6	7.8 ± 1.1	8.1 ± 0.6	5.8 ± 0.1	5.1 ± 0.2	3.0 ± 0.1	2.5 ± 0.1	2.6 ± 0.2	2.0 ± 0.2	1.3 ± 0.0
Stomach	4.5 ± 0.7	4.4 ± 0.4	6.0 ± 1.1	12.3 ± 1.0	8.3 ± 0.2	7.5 ± 0.3	7.0 ± 1.4	6.5 ± 0.5	6.4 ± 0.2	7.4 ± 0.4	6.3 ± 0.6
Small intestine	5.6 ± 0.5	5.5 ± 1.0	4.3 ± 0.5	4.5 ± 0.4	3.1 ± 0.1	2.6 ± 0.3	1.7 ± 0.1	1.7 ± 0.2	2.0 ± 0.2	1.5 ± 0.1	1.2 ± 0.1
Large intestine	2.2 ± 0.1	2.5 ± 0.2	2.7 ± 0.4	3.1 ± 0.1	2.5 ± 0.2	1.8 ± 0.0	1.7 ± 0.1	1.2 ± 0.1	1.4 ± 0.1	1.2 ± 0.1	0.8 ± 0.0
Liver	8.3 ± 0.3	6.8 ± 0.4	5.0 ± 0.6	4.8 ± 0.2	3.2 ± 0.1	2.8 ± 0.2	1.6 ± 0.1	1.3 ± 0.1	1.3 ± 0.1	0.9 ± 0.0	0.7 ± 0.0
Spleen	8.7 ± 0.4	6.1 ± 0.2	5.0 ± 0.7	5.0 ± 0.2	4.6 ± 0.2	4.1 ± 0.2	2.8 ± 0.5	2.6 ± 0.1	2.7 ± 0.5	1.7 ± 0.1	1.4 ± 0.1
Kidneys	19.6 ± 0.7	21.4 ± 1.3	18.6 ± 0.9	16.0 ± 0.8	11.4 ± 0.1	9.3 ± 0.3	5.5 ± 0.3	4.7 ± 0.2	4.0 ± 0.5	2.7 ± 0.1	1.9 ± 0.1
Intraperitoneal fat	3.1 ± 0.4	2.8 ± 0.1	2.8 ± 1.0	2.7 ± 0.3	2.0 ± 0.2	1.9 ± 0.1	1.3 ± 0.1	1.5 ± 0.2	1.4 ± 0.1	1.2 ± 0.1	0.7 ± 0.1
Muscle	2.0 ± 0.9	1.5 ± 0.1	1.3 ± 0.2	1.5 ± 0.1	1.4 ± 0.1	1.2 ± 0.0	0.8 ± 0.0	0.9 ± 0.1	0.8 ± 0.1	0.7 ± 0.0	0.4 ± 0.0
Tumor	2.8 ± 0.1	5.5 ± 0.5	7.3 ± 0.8	11.1 ± 0.5	11.9 ± 0.7	14.0 ± 0.5	14.1 ± 0.9	13.2 ± 0.7	12.1 ± 0.9	10.1 ± 0.4	7.1 ± 0.5

↵* n = 3 for all time points.