Estimated Pharmacokinetic Parameters Derived from Time–Activity Curves of Blood of F98 Glioma-Bearing Fischer 344 Rats After Intracarotid (i.c.) Injection of 18F-FBPA With and Without BBB-D
| Parameter | i.c. | i.c. + BBB-D |
|---|---|---|
| kel (min−1) | 0.0071 ± 0.0014 | 0.0206 ± 0.0018 |
| k12 (min−1) | 0.0160 ± 0.0017 | 0.0260 ± 0.0016 |
| k21 (min−1) | 0.0061 ± 0.0004 | 0.0039 ± 0.0003 |
| V1 (mL) | 3.6 ± 0.1 | 3.1 ± 0.1 |
| k12/k21 | 2.6 ± 0.2 | 6.7 ± 0.5 |
Each point represents mean ± SD of 6 rats.
All P values for comparison of kel, k12, k21, V1, and k12/k21 were <0.01.