Biodistribution of 18F-Nifrolidine in Rats
| Time (min) | % ID/g in various regions | Thalamus-to-cerebellum ratio | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Blood | Thalamus | Cortex | Cerebellum | Control | Before nicotine* | |||||
| 2 | 0.25 ± 0.09 | 0.26 ± 0.05 | 0.21 ± 0.04 | 0.24 ± 0.03 | 1.30 | NT | ||||
| 60 | 0.14 ± 0.03 | 0.37 ± 0.07 | 0.25 ± 0.03 | 0.12 ± 0.02 | 3.08 | 1.8 | ||||
| 120 | 0.04 ± 0.01 | 0.14 ± 0.03 | 0.13 ± 0.04 | 0.10 ± 0.02 | 1.40 | NT | ||||
↵* Rats were preinjected subcutaneously with nicotine ditartarate (10 mg/kg) 5 min before injection of 3.7 MBq of 18F-nifrolidine.
NT = not tested.
Groups of male Sprague–Dawley rats (n = 3) were injected intravenously with 3.7 MBq of 18F-nifrolidine and sacrificed at different times.