Pharmacokinetic Parameters (Mean ± SD) of Ciprofloxacin in Blood and Skeletal Muscle Tissue After Intravenous Administration of a Mixture of 687 ± 50 MBq of 18F-Ciprofloxacin and 200 mg of Unlabeled Ciprofloxacin to 10 healthy Male Volunteers
| Compartment | Cmax (μg/mL) | tmax (min) | t1/2 (min) | AUC0-n (μg · min · mL−1) |
|---|---|---|---|---|
| Plasma | 6.5 ± 0.9 | 10 ± 0 | 208 ± 49 | 290 ± 30 |
| Total tissue [CPET(t)] | 1.8 ± 0.4 | 95 ± 34 | 528 ± 142 | 434 ± 76 |
| Extracellular tissue [Cextra-unbound(t)] | 0.7 ± 0.2 | 48 ± 20 | 233 ± 88 | 132 ± 33 |