TABLE 1

Physiologic Parameters for Glucose and Partial Pressures of CO₂ and O₂

Occlusion	Administration	Dose	n	Glucose (mg/dL)	Partial pressure of CO₂ (mm Hg)	Partial pressure of O₂ (mm Hg)
Before MCA occlusion	Vehicle		6	60.0 ± 7.5	33.2 ± 0.6	156.6 ± 7.1
	TRA-418	Low	6	63.1 ± 8.7	32.8 ± 1.0	167.8 ± 10.6
		High	6	64.4 ± 8.0	34.0 ± 1.1	162.3 ± 9.3
2 h after MCA occlusion	Vehicle		6	69.4 ± 9.6	32.8 ± 0.6	151.4 ± 4.5
	TRA-418	Low	6	73.0 ± 10.1	33.8 ± 0.5	160.3 ± 8.7
		High	6	76.9 ± 11.1	33.5 ± 1.0	144.4 ± 7.7
2 h after reperfusion	Vehicle		6	80.6 ± 13.0	32.4 ± 0.6	148.4 ± 5.2
	TRA-418	Low	6	88.3 ± 14.4	33.4 ± 0.4	155.8 ± 11.3
		High	6	92.3 ± 16.1	31.8 ± 0.9	145.7 ± 13.2
24 h after reperfusion	Vehicle		6	60.4 ± 7.7	32.9 ± 1.7	159.3 ± 12.5
	TRA-418	Low	6	54.3 ± 5.7	33.9 ± 1.5	147.9 ± 12.3
		High	6	59.4 ± 9.9	34.4 ± 0.6	145.6 ± 11.2
4 d after reperfusion	Vehicle		6	68.7 ± 8.3	32.4 ± 0.6	171.3 ± 4.2
	TRA-418	Low	6	91.6 ± 16.1	33.8 ± 0.9	158.9 ± 7.3
		High	6	73.8 ± 9.7	33.2 ± 1.0	156.8 ± 5.2