| Expected | Visual inspections of γ-images for expected biodistribution show the following:
Easily detectable uptake in blood-pool areas on first image, with less activity in blood-pool areas on second or third image Moderately high or high uptake in normal liver and spleen during first and second or third image Moderately low or very low uptake in normal kidneys, lungs, urinary bladder, and normal bowel on first and second or third image Localization to lymphoid aggregates in bowel wall has been reported Tumor uptake may be visualized in soft tissues as areas of increased intensity, and tumor-bearing areas in normal organs may be seen as areas of increased or decreased intensity
|
| Altered | Criteria for altered biodistribution are met if any of the following is detected upon inspection of γ-images:
Rapid clearance of radioimmunoconjugate from blood pool, with prominent liver, spleen, or marrow uptake on first image Diffuse uptake in normal lung more intense than cardiac blood pool on first image or more intense than liver on second or third image Kidneys with greater intensity than liver on posterior view of second or third image Intense areas of uptake throughout normal bowel comparable to uptake by liver on second or third image
|