TABLE 2

Biodistribution (%ID/g) at 180 Minutes of 18F-FMISO and 18F-FAZA in BALB/c Mice Bearing EMT6 Tumor

Tissue18F-FMISO (n = 5)18F-FAZA (n = 8)
Blood1.44 ± 0.260.19 ± 0.19
Heart1.42 ± 0.350.42 ± 0.43
Lung1.50 ± 0.380.39 ± 0.23
Liver4.23 ± 0.820.61 ± 0.62
Spleen1.15 ± 0.270.34 ± 0.13
Kidney1.84 ± 0.490.61 ± 0.28
Brain0.99 ± 0.270.24 ± 0.24
Muscle1.38 ± 0.320.26 ± 0.24
Bone1.52 ± 0.270.50 ± 0.50
Skin0.96 ± 0.220.49 ± 0.48
Stomach2.56 ± 0.460.62 ± 0.25
Small intestine4.00 ± 1.990.76 ± 0.48
Large intestine5.53 ± 2.670.90 ± 0.65
Tumor4.32 ± 0.721.38 ± 0.62*
T/Bl ratio3.03 ± 0.309.82 ± 3.94*
T/M ratio3.22 ± 0.687.10 ± 2.91*
  • * P < 0.01 18F-FMISO vs. 18F-FAZA.

  • Data are presented as mean ± SD.