TABLE 1

Biodistribution (%ID/g) at 180 Minutes of 18F-FMISO and at 10, 60, and 180 Minutes of 18F-FAZA in Swiss Nude Mice Bearing AR42J Tumor

Tissue18F-FMISO18F-FAZA
180 min (n = 5)10 min (n = 6)60 min (n = 6)180 min (n = 8)
Blood0.69 ± 0.193.22 ± 0.660.90 ± 0.130.23 ± 0.26
Heart1.05 ± 0.193.75 ± 0.891.14 ± 0.180.44 ± 0.37
Lung1.32 ± 0.293.48 ± 0.721.05 ± 0.210.46 ± 0.21
Liver4.07 ± 1.435.58 ± 1.062.47 ± 0.460.92 ± 0.71
Spleen0.71 ± 0.213.57 ± 0.820.94 ± 0.070.48 ± 0.17
Kidney1.95 ± 0.447.08 ± 2.022.38 ± 0.351.05 ± 0.42
Brain0.62 ± 0.160.39 ± 0.050.60 ± 0.110.27 ± 0.32
Muscle0.79 ± 0.143.26 ± 0.672.03 ± 1.080.31 ± 0.29
Bone1.31 ± 0.222.27 ± 0.350.74 ± 0.040.42 ± 0.27
Skin1.02 ± 0.263.00 ± 0.602.71 ± 2.610.87 ± 0.21
Stomach1.25 ± 0.253.17 ± 0.511.19 ± 0.130.87 ± 0.43
Small intestine3.61 ± 1.164.30 ± 0.671.88 ± 0.461.22 ± 0.61
Large intestine8.26 ± 4.753.84 ± 0.851.59 ± 0.091.19 ± 0.90
Tumor2.27 ± 0.392.30 ± 1.172.87 ± 1.301.35 ± 0.89*
T/Bl ratio3.39 ± 0.520.73 ± 0.393.27 ± 1.669.06 ± 4.07†
T/M ratio2.92 ± 0.660.72 ± 0.391.69 ± 1.025.49 ± 2.26‡

  • ↵* NS = not significant.

  • ↵† P < 0.01 18F-FMISO vs. 18F-FAZA at 180 min after injection.

  • ↵‡ P < 0.05 18F-FMISO vs. 18F-FAZA at 180 min after injection.

  • Data are presented as mean ± SD.