Proteins Involved in Carbohydrate Metabolism
| Protein | Accession no. | Spot ratio (tumor/normal) | Function | ||
|---|---|---|---|---|---|
| Group A | Group B | ||||
| PPP | |||||
| 6-Phosphogluconolactonase | NP_036220 | 1.2 | 2.5 | 6-Phosphogluconolactone→6-phosphogluconate | |
| TCA cycle | |||||
| Pyruvate carboxylase | P 11498 | 2.0 | 0.3 | Anaplerotic reaction, pyruvate→oxaloacetate | |
| Isocitrate dehydrogenase | NP_005521 | 2.6 | 3.5 | TCA cycle (3rd step), isocitrate→α-ketoglutarate | |
| α-Ketoglutarate dehydrogenase | AAH 26320 | 0.7 | 0.1 | TCA cycle (4th step), α-ketoglutarate→succinyl CoA | |
| β-Succinyl CoA synthetase | AAP 97189 | 1.8 | 2.5 | TCA cycle (5th step), succinyl CoA→succinate | |
| Succinate dehydrogenase | P31040 | 0.4 | 0.2 | TCA cycle (6th step), succinate→fumarate | |
| Fumarase | NP_000134 | 0.7 | 0.5 | TCA cycle (7th step), fumarate→malate | |
| Gluconeogenesis | |||||
| Phosphoenolpyruvate carboxykinase | A45746 | 0.1 | 0.4 | Phosphoenolpyruvate→oxaloacetate | |
| Glyoxylate reductase | NP_036335 | 1.0 | 0.2 | Serine→glucose | |
| Others | |||||
| Mannosephosphate isomerase | NP_002426 | 1.3 | 2.4 | Mannose-6-phosphate→fructose-6-phosphate | |
| Pyruvate kinase | NP_870986 | 0.4 | 0.2 | Phosphoenolpyruvate→pyruvate | |
| Citrate lyase | AAL84703 | 0.7 | 0.3 | Citrate→acetyl CoA | |
| Ketohexokinase | CAA55346 | 0.7 | 0.1 | Fructose→fructose-1-phosphate | |
PPP = pentose phosphate pathway; TCA = tricarboxylic acid; CoA = coenzyme A.