Boron Concentration in Tumor (Tumor [T] Implanted in Left Brain Region), Ipsilateral Brain (IB), Contralateral Brain (CB), and Blood (Bd) of F98 Glioma-Bearing Fischer 344 Rats at 2.5 Hours After Administration of BPA (500 mg/kg) by Various Routes
| Route | Boron concentration (μg/g) | Ratio | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T | IB | CB | Bd | T/IB | T/CB | T/Bd | ||||||
| i.c. + BBB-D | 76.6 ± 12.1 | 12.1 ± 3.5 | 10.1 ± 1.5 | 9.2 ± 2.4 | 6.3 | 7.6 | 8.3 | |||||
| i.c. | 43.1 ± 5.6 | 10.5 ± 0.9 | 9.3 ± 0.2 | 9.5 ± 1.4 | 4.1 | 4.6 | 4.5 | |||||
| i.v. | 19.5 ± 4.5 | 7.8 ± 1.4 | 8.4 ± 1.6 | 9.0 ± 1.2 | 2.5 | 2.3 | 2.2 | |||||
i.c. = intracarotid; i.v. = intravenous.
Each point represents mean ± SD of 5 or 6 rats. Rats were under ketamine mixture anesthesia.