TABLE 3

Biodistribution Data of [^99mTc]Demogastrin 1–3 in AR4-2J Tumor-Bearing Athymic Mice as %ID/g Tissue (Mean ± SD)

Organ	[^99mTc]Demogastrin 1			[^99mTc]Demogastrin 2
Organ		1 h pi	4 h pi	1 h pi	4 h pi	1 h pi
Blood	0.36 ± 0.10	0.15 ± 0.01	0.17 ± 0.02	0.03 ± 0.00	0.35 ± 0.06
Liver	0.34 ± 0.05	1.04 ± 0.09	0.63 ± 0.20	0.38 ± 0.03	2.61 ± 0.49
Heart	0.15 ± 0.04	0.09 ± 0.02	0.30 ± 0.18	0.04 ± 0.00	0.28 ± 0.06
Kidneys	78.97 ± 1.60	41.08 ± 4.21	83.92 ± 14.45	42.65 ± 4.18	78.18 ± 11.85
Blocked kidneys	17.78 ± 0.07^†	20.95 ± 1.27*	27.95 ± 6.49*	14.03 ± 1.84^†	19.50 ± 3.84*
Stomach	6.59 ± 0.50	3.47 ± 0.23	5.86 ± 0.28	3.96 ± 0.26	5.96 ± 0.49
Blocked stomach	1.06 ± 0.08^†	0.45 ± 0.17^†	0.43 ± 0.01^†	0.16 ± 0.03^†	0.41 ± 0.10^†
Intestine	0.62 ± 0.19	1.07 ± 0.16	0.44 ± 0.02	0.54 ± 0.04	0.37 ± 0.03
Spleen	0.17 ± 0.02	0.22 ± 0.40	0.13 ± 0.03	0.10 ± 0.01	0.33 ± 0.09
Muscle	0.12 ± 0.05	0.09 ± 0.00	0.09 ± 0.07	0.02 ± 0.01	0.12 ± 0.05
Lung	0.37 ± 0.05	0.18 ± 0.02	0.54 ± 0.29	0.06 ± 0.01	0.45 ± 0.09
Pancreas	0.28 ± 0.05	0.13 ± 0.01	0.22 ± 0.10	0.09 ± 0.02	0.23 ± 0.02
AR4-2J tumor	6.13 ± 3.28	2.70 ± 1.12	5.50 ± 0.85	2.88 ± 0.42	4.20 ± 1.22
Blocked tumor	0.94 ± 0.42*	0.34 ± 0.01*	0.45 ± 0.07^†	0.17 ± 0.00^†	0.52 ± 0.11*

Student t test was used for statistical analysis; a P value of <0.01 (
↵* P) was considered very significant, whereas a P value of <0.001 (
↵^† P) was considered extremely significant.
pi = after injection.
Results are average of 4 animals per group. Blocking was achieved by coinjection of 250 μg [(D)Glu¹]minigastrin.